Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022270141> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- W2022270141 endingPage "tw91" @default.
- W2022270141 startingPage "tw91" @default.
- W2022270141 abstract "Although the molecular mechanisms of antidepressant action remain unclear, one hypothesis suggests that stimulation of growth factor signaling and of adult neurogenesis in the hippocampus may be implicated in their effects. Warner-Schmidt and Duman investigated the effects of different classes of antidepressants on hippocampal expression of the neurotrophic and pro-angiogenic factor VEGF (vascular endothelial growth factor), which their research group had previously shown to be enhanced by electroconvulsive seizure (ECS) treatment. The abundance of VEGF mRNA increased in the hippocampal granule cell layer of rats treated for 14 days with fluoxetine (a serotonin reuptake inhibitor) or desipramine (a norepinephrine reuptake inhibitor), as did the abundance of VEGF in hippocampal homogenates. Pharmacological blockade of the VEGF receptor Flk-1 inhibited the increase in cell proliferation in the hippocampal subgranular zone (SGZ) produced by ECS or chronic exposure to fluoxetine or desipramine, whereas intracerebroventricular delivery of a VEGF isoform stimulated SGZ cell proliferation. Furthermore, pharmacological blockade of Flk-1 inhibited the effects of desipramine on rat behavioral responses in chronic and subchronic models of antidepressant treatment, whereas VEGF had an antidepressant-like effect. Thus, the authors conclude that VEGF plays a key role in mediating both behavioral effects of several classes of antidepressants and their effects on SGZ cell proliferation. Noting that antidepressants promoted the proliferation of hippocampal endothelial cells as well as hippocampal neurogenesis, the authors speculated that this could play a role in the treatment of certain forms of depression that are associated with vascular abnormalities. J. L. Warner-Schmidt, R. S. Duman, VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proc. Natl. Acad. Sci. U.S.A. 104 , 4647-4652 (2007). [Abstract][Full Text]" @default.
- W2022270141 created "2016-06-24" @default.
- W2022270141 creator A5077591824 @default.
- W2022270141 date "2007-03-14" @default.
- W2022270141 modified "2023-09-23" @default.
- W2022270141 title "Cheering Up with VEGF" @default.
- W2022270141 doi "https://doi.org/10.1126/stke.3782007tw91" @default.
- W2022270141 hasPublicationYear "2007" @default.
- W2022270141 type Work @default.
- W2022270141 sameAs 2022270141 @default.
- W2022270141 citedByCount "0" @default.
- W2022270141 crossrefType "journal-article" @default.
- W2022270141 hasAuthorship W2022270141A5077591824 @default.
- W2022270141 hasConcept C126322002 @default.
- W2022270141 hasConcept C167734588 @default.
- W2022270141 hasConcept C71924100 @default.
- W2022270141 hasConceptScore W2022270141C126322002 @default.
- W2022270141 hasConceptScore W2022270141C167734588 @default.
- W2022270141 hasConceptScore W2022270141C71924100 @default.
- W2022270141 hasIssue "378" @default.
- W2022270141 hasLocation W20222701411 @default.
- W2022270141 hasOpenAccess W2022270141 @default.
- W2022270141 hasPrimaryLocation W20222701411 @default.
- W2022270141 hasRelatedWork W1543694381 @default.
- W2022270141 hasRelatedWork W2551515174 @default.
- W2022270141 hasRelatedWork W2777488335 @default.
- W2022270141 hasRelatedWork W2886176134 @default.
- W2022270141 hasRelatedWork W2902057987 @default.
- W2022270141 hasRelatedWork W3027548153 @default.
- W2022270141 hasRelatedWork W3056157356 @default.
- W2022270141 hasRelatedWork W4230819850 @default.
- W2022270141 hasRelatedWork W4248593563 @default.
- W2022270141 hasRelatedWork W4362490092 @default.
- W2022270141 hasVolume "2007" @default.
- W2022270141 isParatext "false" @default.
- W2022270141 isRetracted "false" @default.
- W2022270141 magId "2022270141" @default.
- W2022270141 workType "article" @default.