FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022270234> ?p ?o ?g. }

• W2022270234 endingPage "4452" @default.
• W2022270234 startingPage "4441" @default.
• W2022270234 abstract "Special AT-rich sequence-binding protein 1 (SATB1) is a ‘genome organizer,’ and it has been proposed as a factor that affects the development and progression of various human neoplasms, including colorectal cancer (CRC). This study aimed to compare SATB1 expression in a group of CRC patients and healthy subjects at the mRNA and protein levels. We collected paired tumor tissue and unchanged mucosa of the large intestine from 102 CRC patients as well as 53 biopsies of normal colon mucosa obtained from healthy patients during screening colonoscopy. Tissue samples were quantified for SATB1 mRNA by quantitative PCR, while SATB1 protein expression was determined by Western blotting and immunohistochemistry. SATB1 mRNA level in tumor tissues was over twofolds lower than in samples of corresponding unchanged tissues and fourfolds lower than in biopsies of healthy colon mucosa. Western blotting analysis revealed that SATB1 protein content in tumor and unchanged tissues of CRC patients was over sixfold and fivefolds higher than in biopsies of healthy colon mucosa, respectively. Immunohistochemical staining demonstrated higher nuclear and cytoplasmic SATB1 reactivity in the tumor tissue compared to unchanged mucosa of CRC patients. Despite these differences, SATB1 mRNA, protein, and immunoreactivity levels did not correlate with patients’ clinicopathological data and their overall survival, but the latter analysis was limited by a relatively short period of follow-up. In conclusion, we suggest that some as yet unidentified posttranscriptional mechanisms that regulate SATB1 expression may be altered in the CRC tissue." @default.
• W2022270234 created "2016-06-24" @default.
• W2022270234 creator A5014093784 @default.
• W2022270234 creator A5015308942 @default.
• W2022270234 creator A5017623761 @default.
• W2022270234 creator A5034350898 @default.
• W2022270234 creator A5037046337 @default.
• W2022270234 creator A5053439340 @default.
• W2022270234 creator A5055976877 @default.
• W2022270234 creator A5059740671 @default.
• W2022270234 creator A5060522042 @default.
• W2022270234 creator A5064063081 @default.
• W2022270234 creator A5064311922 @default.
• W2022270234 date "2015-01-21" @default.
• W2022270234 modified "2023-10-17" @default.
• W2022270234 title "Divergent expression patterns of SATB1 mRNA and SATB1 protein in colorectal cancer and normal tissues" @default.
• W2022270234 cites W1966749931 @default.
• W2022270234 cites W1978334713 @default.
• W2022270234 cites W1981989535 @default.
• W2022270234 cites W1985969740 @default.
• W2022270234 cites W1986342867 @default.
• W2022270234 cites W1994362081 @default.
• W2022270234 cites W1999158919 @default.
• W2022270234 cites W2005856770 @default.
• W2022270234 cites W2006779861 @default.
• W2022270234 cites W2013126388 @default.
• W2022270234 cites W2023016929 @default.
• W2022270234 cites W2062860528 @default.
• W2022270234 cites W2073876158 @default.
• W2022270234 cites W2077273423 @default.
• W2022270234 cites W2081160997 @default.
• W2022270234 cites W2107277218 @default.
• W2022270234 cites W2111024053 @default.
• W2022270234 cites W2115075151 @default.
• W2022270234 cites W2115946406 @default.
• W2022270234 cites W2122026938 @default.
• W2022270234 cites W2128635872 @default.
• W2022270234 cites W2151502444 @default.
• W2022270234 cites W2156475356 @default.
• W2022270234 cites W2168133254 @default.
• W2022270234 cites W2192080449 @default.
• W2022270234 cites W2340386540 @default.
• W2022270234 cites W2410680879 @default.
• W2022270234 cites W4293247451 @default.
• W2022270234 doi "https://doi.org/10.1007/s13277-015-3084-0" @default.
• W2022270234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4529467" @default.
• W2022270234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25874491" @default.
• W2022270234 hasPublicationYear "2015" @default.
• W2022270234 type Work @default.
• W2022270234 sameAs 2022270234 @default.
• W2022270234 citedByCount "17" @default.
• W2022270234 countsByYear W20222702342015 @default.
• W2022270234 countsByYear W20222702342016 @default.
• W2022270234 countsByYear W20222702342017 @default.
• W2022270234 countsByYear W20222702342018 @default.
• W2022270234 countsByYear W20222702342019 @default.
• W2022270234 countsByYear W20222702342021 @default.
• W2022270234 crossrefType "journal-article" @default.
• W2022270234 hasAuthorship W2022270234A5014093784 @default.
• W2022270234 hasAuthorship W2022270234A5015308942 @default.
• W2022270234 hasAuthorship W2022270234A5017623761 @default.
• W2022270234 hasAuthorship W2022270234A5034350898 @default.
• W2022270234 hasAuthorship W2022270234A5037046337 @default.
• W2022270234 hasAuthorship W2022270234A5053439340 @default.
• W2022270234 hasAuthorship W2022270234A5055976877 @default.
• W2022270234 hasAuthorship W2022270234A5059740671 @default.
• W2022270234 hasAuthorship W2022270234A5060522042 @default.
• W2022270234 hasAuthorship W2022270234A5064063081 @default.
• W2022270234 hasAuthorship W2022270234A5064311922 @default.
• W2022270234 hasBestOaLocation W20222702341 @default.
• W2022270234 hasConcept C104317684 @default.
• W2022270234 hasConcept C105580179 @default.
• W2022270234 hasConcept C121608353 @default.
• W2022270234 hasConcept C126322002 @default.
• W2022270234 hasConcept C142724271 @default.
• W2022270234 hasConcept C204232928 @default.
• W2022270234 hasConcept C3019368612 @default.
• W2022270234 hasConcept C48023723 @default.
• W2022270234 hasConcept C502942594 @default.
• W2022270234 hasConcept C526805850 @default.
• W2022270234 hasConcept C55493867 @default.
• W2022270234 hasConcept C71924100 @default.
• W2022270234 hasConcept C85265743 @default.
• W2022270234 hasConcept C86803240 @default.
• W2022270234 hasConceptScore W2022270234C104317684 @default.
• W2022270234 hasConceptScore W2022270234C105580179 @default.
• W2022270234 hasConceptScore W2022270234C121608353 @default.
• W2022270234 hasConceptScore W2022270234C126322002 @default.
• W2022270234 hasConceptScore W2022270234C142724271 @default.
• W2022270234 hasConceptScore W2022270234C204232928 @default.
• W2022270234 hasConceptScore W2022270234C3019368612 @default.
• W2022270234 hasConceptScore W2022270234C48023723 @default.
• W2022270234 hasConceptScore W2022270234C502942594 @default.
• W2022270234 hasConceptScore W2022270234C526805850 @default.
• W2022270234 hasConceptScore W2022270234C55493867 @default.
• W2022270234 hasConceptScore W2022270234C71924100 @default.
• W2022270234 hasConceptScore W2022270234C85265743 @default.
• W2022270234 hasConceptScore W2022270234C86803240 @default.

• next