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- W2022271650 endingPage "751" @default.
- W2022271650 startingPage "744" @default.
- W2022271650 abstract "The perpetuation of most eukaryotic species requires differentiation of pluripotent progenitors into egg and sperm and subsequent fusion of these gametes to form a new zygote. Meiosis is a distinguishing feature of gamete formation as it leads to the twofold reduction in chromosome number thereby maintaining ploidy across generations. This process increases offspring diversity through the random segregation of chromosomes and the exchange of genetic material between homologous parental chromosomes, known as meiotic crossover recombination. These exchanges require the establishment of unique and dynamic chromatin configurations that facilitate cohesion, homolog pairing, synapsis, double strand break formation and repair. The precise orchestration of these events is critical for gamete survival as demonstrated by the majority of human aneuploidies that can be traced to defects in the first meiotic division (Hassold T, Hall H, Hunt P: The origin of human aneuploidy: where we have been, where we are going. Hum Mol Genet 2007, 16 Spec No. 2:R203–R208.). This review will focus on recent advances in our understanding of key meiotic events and how coordination of these events is occurring." @default.
- W2022271650 created "2016-06-24" @default.
- W2022271650 creator A5087430513 @default.
- W2022271650 date "2010-12-01" @default.
- W2022271650 modified "2023-09-24" @default.
- W2022271650 title "Meiosis: making a break for it" @default.
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- W2022271650 doi "https://doi.org/10.1016/j.ceb.2010.08.016" @default.
- W2022271650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3003294" @default.
- W2022271650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20829015" @default.
- W2022271650 hasPublicationYear "2010" @default.