Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022272379> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2022272379 endingPage "5" @default.
- W2022272379 startingPage "1" @default.
- W2022272379 abstract "Morphine-6-sulfate (M6S) and codeine-6-sulfate (C6S) are mu-selective opiates which have been isolated from brain. M6S is an effective analgesic, with a 30-fold greater potency than morphine in the mouse radiant heat tailflick assay and similar to the active morphine metabolite morphine-6beta-glucuronide (M6G). M6S analgesia is reversed by 3-methoxynaltrexone at low antagonist doses which are inactive against morphine, suggesting that M6S may be acting through the same mechanisms as M6G. Consistent with this possibility, antisense mapping of the MOR-1 clone revealed that M6S analgesia was lowered by probes targeting exon 2 and not by targeting exon 1, a sensitivity profile similar to that of M6G and not morphine. C6S also has analgesic activity at doses approximately 10-fold greater than M6S. However, its characterization was impeded by the appearance of seizures at doses below full analgesic activity. Thus, M6S is a potent analgesic with pharmacological properties similar to M6G. C6S has limited utility due to its high level of toxicity." @default.
- W2022272379 created "2016-06-24" @default.
- W2022272379 creator A5018903753 @default.
- W2022272379 creator A5018974125 @default.
- W2022272379 creator A5045651700 @default.
- W2022272379 creator A5056260638 @default.
- W2022272379 creator A5067901889 @default.
- W2022272379 creator A5081392679 @default.
- W2022272379 date "1999-09-01" @default.
- W2022272379 modified "2023-10-17" @default.
- W2022272379 title "Pharmacological characterization of morphine-6-sulfate and codeine-6-sulfate" @default.
- W2022272379 cites W1884781243 @default.
- W2022272379 cites W1975005339 @default.
- W2022272379 cites W1979062392 @default.
- W2022272379 cites W1983059916 @default.
- W2022272379 cites W1992960053 @default.
- W2022272379 cites W2002466677 @default.
- W2022272379 cites W2013581064 @default.
- W2022272379 cites W2013907129 @default.
- W2022272379 cites W2015470203 @default.
- W2022272379 cites W2016026158 @default.
- W2022272379 cites W2017974580 @default.
- W2022272379 cites W2021893815 @default.
- W2022272379 cites W2030268782 @default.
- W2022272379 cites W2038618141 @default.
- W2022272379 cites W2040353422 @default.
- W2022272379 cites W2049805762 @default.
- W2022272379 cites W2050323310 @default.
- W2022272379 cites W2056353612 @default.
- W2022272379 cites W2057854667 @default.
- W2022272379 cites W2072335135 @default.
- W2022272379 cites W2074631079 @default.
- W2022272379 cites W2080843499 @default.
- W2022272379 cites W2120847592 @default.
- W2022272379 cites W2133955100 @default.
- W2022272379 cites W2335669253 @default.
- W2022272379 cites W2403543477 @default.
- W2022272379 doi "https://doi.org/10.1016/s0006-8993(99)01766-7" @default.
- W2022272379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10526089" @default.
- W2022272379 hasPublicationYear "1999" @default.
- W2022272379 type Work @default.
- W2022272379 sameAs 2022272379 @default.
- W2022272379 citedByCount "34" @default.
- W2022272379 countsByYear W20222723792012 @default.
- W2022272379 countsByYear W20222723792013 @default.
- W2022272379 countsByYear W20222723792014 @default.
- W2022272379 countsByYear W20222723792015 @default.
- W2022272379 countsByYear W20222723792016 @default.
- W2022272379 countsByYear W20222723792017 @default.
- W2022272379 countsByYear W20222723792018 @default.
- W2022272379 countsByYear W20222723792020 @default.
- W2022272379 countsByYear W20222723792021 @default.
- W2022272379 countsByYear W20222723792022 @default.
- W2022272379 countsByYear W20222723792023 @default.
- W2022272379 crossrefType "journal-article" @default.
- W2022272379 hasAuthorship W2022272379A5018903753 @default.
- W2022272379 hasAuthorship W2022272379A5018974125 @default.
- W2022272379 hasAuthorship W2022272379A5045651700 @default.
- W2022272379 hasAuthorship W2022272379A5056260638 @default.
- W2022272379 hasAuthorship W2022272379A5067901889 @default.
- W2022272379 hasAuthorship W2022272379A5081392679 @default.
- W2022272379 hasConcept C185592680 @default.
- W2022272379 hasConcept C2777389121 @default.
- W2022272379 hasConcept C2777477808 @default.
- W2022272379 hasConcept C2777866328 @default.
- W2022272379 hasConcept C2780820201 @default.
- W2022272379 hasConcept C55493867 @default.
- W2022272379 hasConcept C71924100 @default.
- W2022272379 hasConcept C98274493 @default.
- W2022272379 hasConceptScore W2022272379C185592680 @default.
- W2022272379 hasConceptScore W2022272379C2777389121 @default.
- W2022272379 hasConceptScore W2022272379C2777477808 @default.
- W2022272379 hasConceptScore W2022272379C2777866328 @default.
- W2022272379 hasConceptScore W2022272379C2780820201 @default.
- W2022272379 hasConceptScore W2022272379C55493867 @default.
- W2022272379 hasConceptScore W2022272379C71924100 @default.
- W2022272379 hasConceptScore W2022272379C98274493 @default.
- W2022272379 hasIssue "1" @default.
- W2022272379 hasLocation W20222723791 @default.
- W2022272379 hasLocation W20222723792 @default.
- W2022272379 hasOpenAccess W2022272379 @default.
- W2022272379 hasPrimaryLocation W20222723791 @default.
- W2022272379 hasRelatedWork W2001815145 @default.
- W2022272379 hasRelatedWork W2014401203 @default.
- W2022272379 hasRelatedWork W2049149756 @default.
- W2022272379 hasRelatedWork W2081365452 @default.
- W2022272379 hasRelatedWork W2128340910 @default.
- W2022272379 hasRelatedWork W2152295954 @default.
- W2022272379 hasRelatedWork W2263632030 @default.
- W2022272379 hasRelatedWork W2293399364 @default.
- W2022272379 hasRelatedWork W2409945781 @default.
- W2022272379 hasRelatedWork W4281486607 @default.
- W2022272379 hasVolume "842" @default.
- W2022272379 isParatext "false" @default.
- W2022272379 isRetracted "false" @default.
- W2022272379 magId "2022272379" @default.
- W2022272379 workType "article" @default.