FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022273483> ?p ?o ?g. }

• W2022273483 endingPage "10673" @default.
• W2022273483 startingPage "10665" @default.
• W2022273483 abstract "ABSTRACT The yeast Saccharomyces cerevisiae Crt1 transcription repressor is an effector of the DNA damage and replication checkpoint pathway. Crt1 binds and represses genes encoding ribonucleotide reductase (RNR) and its own promoter, establishing a negative-feedback pathway. The role of Rfx1, the mammalian Crt1 homologue, remained uncertain. In this study we investigated the possibility that Rfx1 plays a similar function in animal cells. We show here that, like Crt1, Rfx1 binds and represses its own promoter. Furthermore, Rfx1 binding to its promoter is reduced upon induction of a DNA replication block by hydroxyurea, which led to a release of repression. Significantly, like Crt1, Rfx1 binds and represses the RNR-R2 gene. Upon blocking replication and UV treatment, expression of both Rfx1 and RNR-R2 is induced; however, unlike the results seen with the RNR-R2 gene, the derepression of the RFX1 gene is only partially blocked by inhibiting Chk1, the DNA checkpoint kinase. This report provides evidence for a common mechanism for Crt1 and Rfx1 expression and for the conservation of their mode of action in response to a DNA replication block. We suggest that Rfx1 plays a role in the DNA damage response by down-regulating a subset of genes whose expression is increased in response to replication blocking and UV-induced DNA damage." @default.
• W2022273483 created "2016-06-24" @default.
• W2022273483 creator A5016172726 @default.
• W2022273483 creator A5037417005 @default.
• W2022273483 creator A5071233555 @default.
• W2022273483 date "2005-12-01" @default.
• W2022273483 modified "2023-09-25" @default.
• W2022273483 title "Autorepression of Rfx1 Gene Expression: Functional Conservation from Yeast to Humans in Response to DNA Replication Arrest" @default.
• W2022273483 cites W1690106069 @default.
• W2022273483 cites W1818906346 @default.
• W2022273483 cites W1887764107 @default.
• W2022273483 cites W1892377031 @default.
• W2022273483 cites W1952865218 @default.
• W2022273483 cites W1962459157 @default.
• W2022273483 cites W1964027566 @default.
• W2022273483 cites W1969799867 @default.
• W2022273483 cites W1974425687 @default.
• W2022273483 cites W1976922448 @default.
• W2022273483 cites W1982122702 @default.
• W2022273483 cites W1995094827 @default.
• W2022273483 cites W1995635036 @default.
• W2022273483 cites W1996818234 @default.
• W2022273483 cites W2000137331 @default.
• W2022273483 cites W2014465548 @default.
• W2022273483 cites W2016288128 @default.
• W2022273483 cites W2016645839 @default.
• W2022273483 cites W2023722203 @default.
• W2022273483 cites W2023724309 @default.
• W2022273483 cites W2031609286 @default.
• W2022273483 cites W2035983301 @default.
• W2022273483 cites W2038783205 @default.
• W2022273483 cites W2044882923 @default.
• W2022273483 cites W2056783112 @default.
• W2022273483 cites W2068584925 @default.
• W2022273483 cites W2073856024 @default.
• W2022273483 cites W2075039339 @default.
• W2022273483 cites W2076040989 @default.
• W2022273483 cites W2079712794 @default.
• W2022273483 cites W2080130983 @default.
• W2022273483 cites W2083167125 @default.
• W2022273483 cites W2083970447 @default.
• W2022273483 cites W2085972813 @default.
• W2022273483 cites W2109641699 @default.
• W2022273483 cites W2110468189 @default.
• W2022273483 cites W2112481873 @default.
• W2022273483 cites W2116735732 @default.
• W2022273483 cites W2126537212 @default.
• W2022273483 cites W2128252882 @default.
• W2022273483 cites W2135940271 @default.
• W2022273483 cites W2142673763 @default.
• W2022273483 cites W2152523782 @default.
• W2022273483 cites W2153057184 @default.
• W2022273483 cites W2153563795 @default.
• W2022273483 cites W2154141161 @default.
• W2022273483 cites W2162735386 @default.
• W2022273483 cites W2171109371 @default.
• W2022273483 cites W2312775319 @default.
• W2022273483 doi "https://doi.org/10.1128/mcb.25.23.10665-10673.2005" @default.
• W2022273483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1291218" @default.
• W2022273483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16287876" @default.
• W2022273483 hasPublicationYear "2005" @default.
• W2022273483 type Work @default.
• W2022273483 sameAs 2022273483 @default.
• W2022273483 citedByCount "51" @default.
• W2022273483 countsByYear W20222734832012 @default.
• W2022273483 countsByYear W20222734832013 @default.
• W2022273483 countsByYear W20222734832014 @default.
• W2022273483 countsByYear W20222734832015 @default.
• W2022273483 countsByYear W20222734832016 @default.
• W2022273483 countsByYear W20222734832017 @default.
• W2022273483 countsByYear W20222734832018 @default.
• W2022273483 countsByYear W20222734832019 @default.
• W2022273483 countsByYear W20222734832020 @default.
• W2022273483 countsByYear W20222734832021 @default.
• W2022273483 countsByYear W20222734832023 @default.
• W2022273483 crossrefType "journal-article" @default.
• W2022273483 hasAuthorship W2022273483A5016172726 @default.
• W2022273483 hasAuthorship W2022273483A5037417005 @default.
• W2022273483 hasAuthorship W2022273483A5071233555 @default.
• W2022273483 hasBestOaLocation W20222734832 @default.
• W2022273483 hasConcept C104292427 @default.
• W2022273483 hasConcept C104317684 @default.
• W2022273483 hasConcept C134935766 @default.
• W2022273483 hasConcept C143425029 @default.
• W2022273483 hasConcept C150194340 @default.
• W2022273483 hasConcept C153911025 @default.
• W2022273483 hasConcept C158448853 @default.
• W2022273483 hasConcept C186310378 @default.
• W2022273483 hasConcept C4710235 @default.
• W2022273483 hasConcept C54355233 @default.
• W2022273483 hasConcept C552990157 @default.
• W2022273483 hasConcept C73573662 @default.
• W2022273483 hasConcept C73766848 @default.
• W2022273483 hasConcept C86339819 @default.
• W2022273483 hasConcept C86803240 @default.
• W2022273483 hasConcept C94966510 @default.
• W2022273483 hasConceptScore W2022273483C104292427 @default.
• W2022273483 hasConceptScore W2022273483C104317684 @default.

• next