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• W2022273679 abstract "Background: Rap1- specific GTPase-activating protein (rap1GAP) is significantly down regulated in pancreatic cancer and is a candidate tumor suppressor gene located on chromosome 1p35-36. We hypothesized that loss of rap1GAP correlated with negative histological parameters and decreased patient survival. Methods: Immunohistochemical staining for Rap1GAP was performed in 112 cases of conventional pancreatic ductal adenocarcinoma (PDA). Based on the degree of expression level (calculated by an established scoring system incorporating the percentage of + labeled carcinoma cells and the intensity of labeling), each case was assigned to one of 4 categories: 0-none, 1-minimal, 2-moderate, and 3-significant. Expression levels were correlated with the archival data available on some patients on DPC4, kras, p53, p21, p27, and Fas ligand expression as well as clinical data including patient survival. Results: Rap1GAP was normally expressed in all components of normal pancreas. Some degree of immunohistochemical labeling of Rap1GAP (IER) was detected in 98/112 (88%) of the PDA cases: The expression level was minimal in 60, moderate in 13, and significant in 25 cases. The IER tended to be higher in patients <50 yrs old (average IER 1.85 vs. 1.40), in smokers (1.71 vs. 1.21), carcinomas in the head (1.55 vs. 1.21 in tail) and those with no family history of pancreatic cancer (2.0 vs. 1.62). No significant correlation was identified between IER and tumor size (> vs. <2 cm: 1.42 vs. 1.62) or lymph node status (pos vs. neg: 1.48 vs. 1.45). With Spearman rank correlation p27 and Rap1GAP expression had a marginally significant correlation (p = 0.05). When Kaplan-Maier survival curves were analyzed, the most significant grouping was between 0-no expression vs. 1, 2, or 3 expressors of Rap1GAP. In univariate analysis, loss of expression was associated with a shorter survival (p = 0.003). In a Cox-proportional Hazard model incorporating tumor stage, grade, lymph node status and Rap1 GAP, the significance of Rap1GAP expression persisted (p = 0.03). Conclusions: Decreased or loss of Rap1-GAP expression correlated with poor histological parameters and decreased survival in patients with PDA, supporting the role of Rap1GAP as a functionally important tumor suppressor gene in pancreatic cancer." @default.
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• W2022273679 date "2005-11-01" @default.
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• W2022273679 title "RAP1GAP EXPRESSION IN PANCREATIC DUCTAL ADENOCARCINOMA: CORRELATION WITH THE CLINICOPATHOLOGIC PARAMETERS" @default.
• W2022273679 doi "https://doi.org/10.1097/01.mpa.0000193692.83082.75" @default.
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