Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022274425> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2022274425 abstract "spectively, compared to untreated cells as determined in caspase 3/7assays (n = 4, each). Pharmacologic inhibition of p110 gamma significantly reduced apoptosis to 38%, 14%, 40% and 30% of these levels, respectively (n = 4, p< 0.05). Transient siRNA-transfection diminished apoptosis to 62%, 32%, 30% and 37% of apoptosis levels (n = 3) of sham transfected cells. Morphologic determination of apoptosis showed comparable results. Etoposide and TNFalpha/actinomycin D induced a 2±1and 13±6-fold increase in caspase 3/7 activity, which was not affected by p110 gamma inhibition (n = 4). Similar results were obtained in Huh7-Ntcp cells. Conclusions: Bile salt induced apoptosis, but not apoptosis induced by other stimuli, is mediated, at least in part, through activation of the p110 gamma isoform of PI3K. Selective inhibition of p110 gamma PI3K could be a novel approach to reduce hepatocyte apoptosis, thereby ameliorating liver injury in cholestasis." @default.
- W2022274425 created "2016-06-24" @default.
- W2022274425 creator A5001537363 @default.
- W2022274425 creator A5002355334 @default.
- W2022274425 creator A5002575555 @default.
- W2022274425 creator A5046642915 @default.
- W2022274425 creator A5054129614 @default.
- W2022274425 creator A5073319609 @default.
- W2022274425 date "2009-04-01" @default.
- W2022274425 modified "2023-09-26" @default.
- W2022274425 title "243 TRANSLATION INHIBITORS SENSITIZE HEPATOMA CELLS TO APOPTOSIS INDUCED BY TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) BY ENHANCING BID CLEAVAGE" @default.
- W2022274425 doi "https://doi.org/10.1016/s0168-8278(09)60245-2" @default.
- W2022274425 hasPublicationYear "2009" @default.
- W2022274425 type Work @default.
- W2022274425 sameAs 2022274425 @default.
- W2022274425 citedByCount "0" @default.
- W2022274425 crossrefType "journal-article" @default.
- W2022274425 hasAuthorship W2022274425A5001537363 @default.
- W2022274425 hasAuthorship W2022274425A5002355334 @default.
- W2022274425 hasAuthorship W2022274425A5002575555 @default.
- W2022274425 hasAuthorship W2022274425A5046642915 @default.
- W2022274425 hasAuthorship W2022274425A5054129614 @default.
- W2022274425 hasAuthorship W2022274425A5073319609 @default.
- W2022274425 hasConcept C104317684 @default.
- W2022274425 hasConcept C12519072 @default.
- W2022274425 hasConcept C126322002 @default.
- W2022274425 hasConcept C134018914 @default.
- W2022274425 hasConcept C153911025 @default.
- W2022274425 hasConcept C17991360 @default.
- W2022274425 hasConcept C185592680 @default.
- W2022274425 hasConcept C190283241 @default.
- W2022274425 hasConcept C2776694085 @default.
- W2022274425 hasConcept C2778119113 @default.
- W2022274425 hasConcept C2778593092 @default.
- W2022274425 hasConcept C31573885 @default.
- W2022274425 hasConcept C502942594 @default.
- W2022274425 hasConcept C54009773 @default.
- W2022274425 hasConcept C55493867 @default.
- W2022274425 hasConcept C66008609 @default.
- W2022274425 hasConcept C71924100 @default.
- W2022274425 hasConcept C86554907 @default.
- W2022274425 hasConcept C86803240 @default.
- W2022274425 hasConceptScore W2022274425C104317684 @default.
- W2022274425 hasConceptScore W2022274425C12519072 @default.
- W2022274425 hasConceptScore W2022274425C126322002 @default.
- W2022274425 hasConceptScore W2022274425C134018914 @default.
- W2022274425 hasConceptScore W2022274425C153911025 @default.
- W2022274425 hasConceptScore W2022274425C17991360 @default.
- W2022274425 hasConceptScore W2022274425C185592680 @default.
- W2022274425 hasConceptScore W2022274425C190283241 @default.
- W2022274425 hasConceptScore W2022274425C2776694085 @default.
- W2022274425 hasConceptScore W2022274425C2778119113 @default.
- W2022274425 hasConceptScore W2022274425C2778593092 @default.
- W2022274425 hasConceptScore W2022274425C31573885 @default.
- W2022274425 hasConceptScore W2022274425C502942594 @default.
- W2022274425 hasConceptScore W2022274425C54009773 @default.
- W2022274425 hasConceptScore W2022274425C55493867 @default.
- W2022274425 hasConceptScore W2022274425C66008609 @default.
- W2022274425 hasConceptScore W2022274425C71924100 @default.
- W2022274425 hasConceptScore W2022274425C86554907 @default.
- W2022274425 hasConceptScore W2022274425C86803240 @default.
- W2022274425 hasLocation W20222744251 @default.
- W2022274425 hasOpenAccess W2022274425 @default.
- W2022274425 hasPrimaryLocation W20222744251 @default.
- W2022274425 hasRelatedWork W1570044629 @default.
- W2022274425 hasRelatedWork W1977327767 @default.
- W2022274425 hasRelatedWork W1993887799 @default.
- W2022274425 hasRelatedWork W2025963778 @default.
- W2022274425 hasRelatedWork W2029454833 @default.
- W2022274425 hasRelatedWork W2040158378 @default.
- W2022274425 hasRelatedWork W2040263391 @default.
- W2022274425 hasRelatedWork W2057067795 @default.
- W2022274425 hasRelatedWork W2093903224 @default.
- W2022274425 hasRelatedWork W2109284866 @default.
- W2022274425 hasRelatedWork W2144468407 @default.
- W2022274425 hasRelatedWork W2324600056 @default.
- W2022274425 hasRelatedWork W2375163710 @default.
- W2022274425 hasRelatedWork W2559924135 @default.
- W2022274425 hasRelatedWork W2581825693 @default.
- W2022274425 hasRelatedWork W2917246512 @default.
- W2022274425 hasRelatedWork W2963972381 @default.
- W2022274425 hasRelatedWork W3029524629 @default.
- W2022274425 hasRelatedWork W3150058679 @default.
- W2022274425 hasRelatedWork W2468699361 @default.
- W2022274425 isParatext "false" @default.
- W2022274425 isRetracted "false" @default.
- W2022274425 magId "2022274425" @default.
- W2022274425 workType "article" @default.