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- W2022274670 abstract "Abstract Docetaxel (Taxotere®) is an accepted chemotherapeutic agent for the treatment of breast cancer and non‐small cell lung cancers. A potential means of predicting response is measuring tumor uptake of [ 11 C]docetaxel using Positron Emission Tomography (PET). The synthetic approach to introduce the 11 C isotope in the 2‐benzoyl moiety of docetaxel unfortunately was unsuccessful. The radiosynthesis of [ 11 C]docetaxel ( 6b , Scheme 1), with the 11 C isotope in the BOC moiety, was however, successful using a second synthetic approach. It started with the reaction of [ 11 C] tert ‐butanol with 1,2,2,2‐tetrachloroethyl chloroformate to give [ 11 C] tert ‐butyl‐l,2,2,2‐tetrachloroethyl carbonate in a good overall yield (62±9%). In the final step, the [ 11 C] tert ‐butoxycarbonylation of the free amine of docetaxel gave [ 11 C]docetaxel 6b in a satisfactory decay corrected yield of 10±1% (from [ 11 C]CO 2 ). Copyright © 2004 John Wiley & Sons, Ltd." @default.
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- W2022274670 date "2004-08-25" @default.
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- W2022274670 title "Radiosynthesis of[11C]docetaxel" @default.
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- W2022274670 doi "https://doi.org/10.1002/jlcr.861" @default.
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