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- W2022274678 abstract "Injection of endotoxin in D-galactosamine sensitized mice resulted in increased serum levels of tumor necrosis factor as determined in a fibroblast cytolysis assay. Concomitant injection of different lipoxygenase inhibitors decreased the titer of TNF. When the lipoxygenase inhibitors were tested in macrophage cultures stimulated with LPS, they prevented the production of TNF. Indomethacin, a blocker of cycclooxygenase was neither in>vivo nor in, vitro effective in the prevention of the endotoxin-induced synthesis of TNF. The involvement of superoxide anion in this effect was excluded by use of superoxide dismutase which did not influence the formation of TNF in macrophages." @default.
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- W2022274678 title "Lipoxygenase inhibitors suppress formation of tumor necrosis factor in, vitro and in, vivo" @default.
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- W2022274678 doi "https://doi.org/10.1016/0006-291x(89)90058-2" @default.
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