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• W2022274859 abstract "Lymph nodes are strategically located throughout the body to allow lymphocytes to efficiently encounter their cognate antigen and become activated. The structure of the lymph nodes is such that B and T lymphocytes each have their own microdomain. This structure is provided by lymph node stromal cells, which also provide the lymphocytes with a scaffold upon which to migrate. Here, we discuss how stromal cells differentiate from mesenchymal precursor cells in response to the interaction with lymphocytes, while these stromal cells in turn provide necessary survival factors for the lymphocytes. We propose that during immune reactions, the interactions of stromal and immune cells are similarly important for controlling the expanding lymphocyte pool. Lymph nodes are strategically located throughout the body to allow lymphocytes to efficiently encounter their cognate antigen and become activated. The structure of the lymph nodes is such that B and T lymphocytes each have their own microdomain. This structure is provided by lymph node stromal cells, which also provide the lymphocytes with a scaffold upon which to migrate. Here, we discuss how stromal cells differentiate from mesenchymal precursor cells in response to the interaction with lymphocytes, while these stromal cells in turn provide necessary survival factors for the lymphocytes. We propose that during immune reactions, the interactions of stromal and immune cells are similarly important for controlling the expanding lymphocyte pool." @default.
• W2022274859 created "2016-06-24" @default.
• W2022274859 creator A5007422098 @default.
• W2022274859 creator A5057308125 @default.
• W2022274859 date "2012-06-01" @default.
• W2022274859 modified "2023-10-16" @default.
• W2022274859 title "Interdependence of stromal and immune cells for lymph node function" @default.
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• W2022274859 doi "https://doi.org/10.1016/j.it.2011.10.006" @default.
• W2022274859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22153930" @default.
• W2022274859 hasPublicationYear "2012" @default.
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