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- W2022274936 abstract "To investigate how early events in antigen processing affect the repertoire of peptides presented by MHC class I molecules, we compared the presentation of the influenza A nucleoprotein epitope 265 – 273 by HLA-A3 class I molecules in human and mouse cells. Mouse cells that express HLA-A3 failed to present the NP265 – 273 peptide when contained within the full-length nucleoprotein, to HLA-A3-restricted human cytotoxic T lymphocytes. However, when the epitope was generated directly in the cytosol using a recombinant vaccinia virus that expressed the nonamer peptide, mouse cells were recognized by HLA-A3-restricted CTL. Poor transport of the peptide by mouse TAP was not responsible for the defect as co-infection of mouse cells with recombinant vaccinia viruses encoding the full-length nucleoprotein and the human TAP1 and TAP2 peptide transporter complex failed to restore presentation. These results therefore demonstrate a differential processing of the influenza nucleoprotein in mouse and human cells. This polymorphism influences the repertoire of peptides presented by MHC class I molecules at the cell surface." @default.
- W2022274936 created "2016-06-24" @default.
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- W2022274936 date "1998-02-01" @default.
- W2022274936 modified "2023-10-03" @default.
- W2022274936 title "Differential processing of influenza nucleoprotein in human and mouse cells" @default.
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- W2022274936 doi "https://doi.org/10.1002/(sici)1521-4141(199802)28:02<625::aid-immu625>3.0.co;2-i" @default.
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