FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022275623> ?p ?o ?g. }

• W2022275623 endingPage "1003" @default.
• W2022275623 startingPage "999" @default.
• W2022275623 abstract "Synaptotagmin I or II (Syt I/II) is involved in Ca2+-regulated exocytosis of secretory vesicles, probably serving as a Ca2+-sensor via its C2A domain. Synaptotagmin is also known to be expressed in neuronal growth cone vesicles, but its functional involvement in neurite outgrowth remains largely unknown. In this study, we examined the function of Syt I/II in neurite outgrowth in cultured chick dorsal root ganglion neurons using an anti-synaptotagmin I and II C2A domain (anti-STI/II-C2A) antibody that inhibits Ca2+-regulated exocytosis. Immunoblots confirmed the high specificity of the anti-STI/II-C2A antibody and showed the expression of synaptotagmin I or II in chick dorsal root ganglion neurons. Immunocytochemistry revealed that synaptotagmin I or II is enriched at the growth cone region of chick dorsal root ganglion neurons, in both lamellipodia and filopodia. Whole or Fab-fragment of the anti-STI/II-C2A antibody loaded into dorsal root ganglion neurons by trituration significantly inhibited neurite outgrowth, whereas preimmune IgG had no effect. These results showed that the C2A domain of synaptotagmin I or II plays a crucial role in neurite outgrowth." @default.
• W2022275623 created "2016-06-24" @default.
• W2022275623 creator A5004475963 @default.
• W2022275623 creator A5006129467 @default.
• W2022275623 creator A5018040872 @default.
• W2022275623 creator A5035555934 @default.
• W2022275623 creator A5046809342 @default.
• W2022275623 date "1999-02-01" @default.
• W2022275623 modified "2023-10-07" @default.
• W2022275623 title "Functional involvement of synaptotagmin I/II C2A domain in neurite outgrowth of chick dorsal root ganglion neuron" @default.
• W2022275623 cites W1490238549 @default.
• W2022275623 cites W1521404049 @default.
• W2022275623 cites W1529696685 @default.
• W2022275623 cites W1544609822 @default.
• W2022275623 cites W1970930136 @default.
• W2022275623 cites W1981528650 @default.
• W2022275623 cites W1991937669 @default.
• W2022275623 cites W1992421008 @default.
• W2022275623 cites W1997046039 @default.
• W2022275623 cites W2000237826 @default.
• W2022275623 cites W2000242561 @default.
• W2022275623 cites W2011556695 @default.
• W2022275623 cites W2018757497 @default.
• W2022275623 cites W2029160544 @default.
• W2022275623 cites W2036006235 @default.
• W2022275623 cites W2040589125 @default.
• W2022275623 cites W2046872857 @default.
• W2022275623 cites W2062699559 @default.
• W2022275623 cites W2068803610 @default.
• W2022275623 cites W2085287004 @default.
• W2022275623 cites W2087938584 @default.
• W2022275623 cites W2092562744 @default.
• W2022275623 cites W2096721619 @default.
• W2022275623 cites W2105252992 @default.
• W2022275623 cites W2109809176 @default.
• W2022275623 cites W2110945660 @default.
• W2022275623 cites W2125178516 @default.
• W2022275623 cites W2136422440 @default.
• W2022275623 cites W2162152321 @default.
• W2022275623 doi "https://doi.org/10.1016/s0306-4522(98)00547-8" @default.
• W2022275623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10336114" @default.
• W2022275623 hasPublicationYear "1999" @default.
• W2022275623 type Work @default.
• W2022275623 sameAs 2022275623 @default.
• W2022275623 citedByCount "32" @default.
• W2022275623 countsByYear W20222756232012 @default.
• W2022275623 countsByYear W20222756232016 @default.
• W2022275623 countsByYear W20222756232020 @default.
• W2022275623 countsByYear W20222756232023 @default.
• W2022275623 crossrefType "journal-article" @default.
• W2022275623 hasAuthorship W2022275623A5004475963 @default.
• W2022275623 hasAuthorship W2022275623A5006129467 @default.
• W2022275623 hasAuthorship W2022275623A5018040872 @default.
• W2022275623 hasAuthorship W2022275623A5035555934 @default.
• W2022275623 hasAuthorship W2022275623A5046809342 @default.
• W2022275623 hasConcept C105702510 @default.
• W2022275623 hasConcept C113246987 @default.
• W2022275623 hasConcept C125705527 @default.
• W2022275623 hasConcept C130316041 @default.
• W2022275623 hasConcept C134018914 @default.
• W2022275623 hasConcept C135903288 @default.
• W2022275623 hasConcept C140530291 @default.
• W2022275623 hasConcept C148785051 @default.
• W2022275623 hasConcept C175969161 @default.
• W2022275623 hasConcept C185592680 @default.
• W2022275623 hasConcept C202751555 @default.
• W2022275623 hasConcept C2776281502 @default.
• W2022275623 hasConcept C2779530196 @default.
• W2022275623 hasConcept C2909695770 @default.
• W2022275623 hasConcept C35866371 @default.
• W2022275623 hasConcept C41625074 @default.
• W2022275623 hasConcept C49039625 @default.
• W2022275623 hasConcept C55493867 @default.
• W2022275623 hasConcept C86473631 @default.
• W2022275623 hasConcept C86803240 @default.
• W2022275623 hasConcept C90301020 @default.
• W2022275623 hasConcept C95444343 @default.
• W2022275623 hasConceptScore W2022275623C105702510 @default.
• W2022275623 hasConceptScore W2022275623C113246987 @default.
• W2022275623 hasConceptScore W2022275623C125705527 @default.
• W2022275623 hasConceptScore W2022275623C130316041 @default.
• W2022275623 hasConceptScore W2022275623C134018914 @default.
• W2022275623 hasConceptScore W2022275623C135903288 @default.
• W2022275623 hasConceptScore W2022275623C140530291 @default.
• W2022275623 hasConceptScore W2022275623C148785051 @default.
• W2022275623 hasConceptScore W2022275623C175969161 @default.
• W2022275623 hasConceptScore W2022275623C185592680 @default.
• W2022275623 hasConceptScore W2022275623C202751555 @default.
• W2022275623 hasConceptScore W2022275623C2776281502 @default.
• W2022275623 hasConceptScore W2022275623C2779530196 @default.
• W2022275623 hasConceptScore W2022275623C2909695770 @default.
• W2022275623 hasConceptScore W2022275623C35866371 @default.
• W2022275623 hasConceptScore W2022275623C41625074 @default.
• W2022275623 hasConceptScore W2022275623C49039625 @default.
• W2022275623 hasConceptScore W2022275623C55493867 @default.
• W2022275623 hasConceptScore W2022275623C86473631 @default.
• W2022275623 hasConceptScore W2022275623C86803240 @default.
• W2022275623 hasConceptScore W2022275623C90301020 @default.

• next