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• W2022276324 abstract "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolite 1-methyl-4-phenylpyridium ion (MPP(+)) have been shown to induce Parkinson's disease-like symptoms as well as neurotoxicity in humans and animal species. Recently, we reported that maintenance of redox balance and cellular defense against oxidative damage are primary functions of the novel antioxidant enzyme cytosolic NADP(+) -dependent isocitrate dehydrogenase (IDPc). In this study, we examined the role of IDPc in cellular defense against MPP(+) -induced oxidative injury using PC12 cells transfected with IDPc small interfering RNA (siRNA). Our results demonstrate that MPP(+) -mediated disruption of cellular redox status, oxidative damage to cells, and apoptotic cell death were significantly enhanced by knockdown of IDPc." @default.
• W2022276324 created "2016-06-24" @default.
• W2022276324 creator A5016006113 @default.
• W2022276324 creator A5090237506 @default.
• W2022276324 date "2011-05-31" @default.
• W2022276324 modified "2023-10-03" @default.
• W2022276324 title "Knockdown of cytosolic NADP⁺-dependent isocitrate dehydrogenase enhances MPP⁺-induced oxidative injury in PC12 cells" @default.
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• W2022276324 doi "https://doi.org/10.5483/bmbrep.2011.44.5.312" @default.
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