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• W2022276433 abstract "Objective To assess the effects of viral interleukin-10 (vIL-10) gene delivery on human rheu matoid synovial tissue. Methods SCID mice were engrafted subcutaneously with human rheumatoid synovial tissue and homologous cartilage before systemic injection of 109 plaque-forming units of type 5 E1a E1b–deficient nonreplicative adenovirus vector containing the vIL-10 gene under control of the cytomegalovirus promoter (AdvIL-10; n = 10) or a control gene (AdvIL-10mut; n = 7). Three weeks later, the graft was removed for histologic analysis of cartilage invasion by synovial tissue. The number of CD3-positive mononuclear cells was assessed in the synovial tissue by immunohistology. Messenger RNA (mRNA) expression of matrix metalloproteinase 3 (MMP-3), tissue inhibitor of metalloproteinases 1 (TIMP-1), and proinflammatory cytokines was determined by polymerase chain reaction. Results Systemic vIL-10 gene transfer resulted in high sustained production of vIL-10 protein in SCID mouse sera (mean ± SD 25 ± 5 ng/ml on day 40 post vector injection). Moreover, vIL-10 mRNA expression was detected in the synovial tissue 3 weeks after intravenous injection of AdvIL-10, reflecting the gene transfer in the human graft. In animals treated with AdvIL-10, cartilage invasion by rheumatoid synovial tissue was significantly inhibited compared with the control vector (mean ± SD histologic score 2.5 ± 0.52 versus 0.75 ± 0.8; P < 0.0001). The number of T cells infiltrating the synovium and perichondral resorption in the animals treated with AdvIL-10 gene were not significantly modified relative to the control vector. In animals treated with AdvIL-10, the MMP-3–TIMP-1 balance was partially restored, independent of the effect on mRNA expression of tumor necrosis factor α, IL-1, IL-6, or IL-8. Conclusion Systemic vIL-10 gene transfer prevented cartilage invasion by synovial tissue engrafted in SCID mice. This model offers the opportunity to study the biologic effects of gene transfer in vivo in rheumatoid synovium." @default.
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• W2022276433 date "1999-04-01" @default.
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• W2022276433 title "Systemic viral interleukin-10 gene delivery prevents cartilage invasion by human rheumatoid synovial tissue engrafted in SCID mice" @default.
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• W2022276433 doi "https://doi.org/10.1002/1529-0131(199904)42:4<678::aid-anr10>3.0.co;2-s" @default.
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