FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022278218> ?p ?o ?g. }

• W2022278218 endingPage "277" @default.
• W2022278218 startingPage "270" @default.
• W2022278218 abstract "The effects of specific renin inhibitors, angiotensin converting enzyme inhibitors, indomethacin, and prostaglandin I2 analogue on the release of angiotensins from isolated and Krebs-Ringer-perfused rabbit mesenteric arteries were examined. Three different renin inhibitors suppressed release of angiotensins in dose-dependent manners. At the highest concentration (10(-7) M), the inhibitors EMD 52,620, EMD 54,388, and EMD 52,742 induced 46%, 52%, and 48% decreases, respectively, in the basal rate of immunoreactive angiotensin II release. These results provide clear evidence that released angiotensins are produced by the specific action of vascular renin and that the renin inhibitors suppress the vascular renin-angiotensin system as well as the circulating renin-angiotensin system and appear to provide a useful mode for the treatment of hypertension. Nonsulfhydryl angiotensin converting enzyme inhibitors cilazapril and delapril were more effective than captopril, and ramipril was equipotent to captopril, suggesting that the effectiveness of angiotensin converting enzyme inhibitors on the vascular renin-angiotensin system cannot be explained only by its inhibitory effect on angiotensin converting enzyme. Indomethacin, which was reported to suppress angiotensin II release from rat hind limbs, elicited a dose-dependent increase of angiotensin release from rabbit mesenteric arteries. These results suggest that a difference exists in the regulatory mechanisms in the release of angiotensins from diverse vascular beds." @default.
• W2022278218 created "2016-06-24" @default.
• W2022278218 creator A5009145682 @default.
• W2022278218 creator A5010738066 @default.
• W2022278218 creator A5058845872 @default.
• W2022278218 creator A5088216068 @default.
• W2022278218 date "1991-03-01" @default.
• W2022278218 modified "2023-09-26" @default.
• W2022278218 title "Significance of vascular renin for local generation of angiotensins." @default.
• W2022278218 cites W1517578770 @default.
• W2022278218 cites W1911188572 @default.
• W2022278218 cites W1982962960 @default.
• W2022278218 cites W1985990134 @default.
• W2022278218 cites W1994138763 @default.
• W2022278218 cites W1999022133 @default.
• W2022278218 cites W2000515863 @default.
• W2022278218 cites W2006938020 @default.
• W2022278218 cites W2009806656 @default.
• W2022278218 cites W2014684729 @default.
• W2022278218 cites W2024912244 @default.
• W2022278218 cites W2027125938 @default.
• W2022278218 cites W2033139020 @default.
• W2022278218 cites W2035319594 @default.
• W2022278218 cites W2037514881 @default.
• W2022278218 cites W2040427276 @default.
• W2022278218 cites W2040803575 @default.
• W2022278218 cites W2051116353 @default.
• W2022278218 cites W2053613216 @default.
• W2022278218 cites W2060608101 @default.
• W2022278218 cites W2079919447 @default.
• W2022278218 cites W2095634234 @default.
• W2022278218 cites W2115207865 @default.
• W2022278218 cites W2125121133 @default.
• W2022278218 cites W2128131090 @default.
• W2022278218 cites W2171251866 @default.
• W2022278218 cites W2420567774 @default.
• W2022278218 cites W2768445808 @default.
• W2022278218 doi "https://doi.org/10.1161/01.hyp.17.3.270" @default.
• W2022278218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1999357" @default.
• W2022278218 hasPublicationYear "1991" @default.
• W2022278218 type Work @default.
• W2022278218 sameAs 2022278218 @default.
• W2022278218 citedByCount "19" @default.
• W2022278218 crossrefType "journal-article" @default.
• W2022278218 hasAuthorship W2022278218A5009145682 @default.
• W2022278218 hasAuthorship W2022278218A5010738066 @default.
• W2022278218 hasAuthorship W2022278218A5058845872 @default.
• W2022278218 hasAuthorship W2022278218A5088216068 @default.
• W2022278218 hasBestOaLocation W20222782181 @default.
• W2022278218 hasConcept C123915805 @default.
• W2022278218 hasConcept C126322002 @default.
• W2022278218 hasConcept C134018914 @default.
• W2022278218 hasConcept C170493617 @default.
• W2022278218 hasConcept C181199279 @default.
• W2022278218 hasConcept C185592680 @default.
• W2022278218 hasConcept C198710026 @default.
• W2022278218 hasConcept C27016395 @default.
• W2022278218 hasConcept C2776820930 @default.
• W2022278218 hasConcept C2776980637 @default.
• W2022278218 hasConcept C2779479957 @default.
• W2022278218 hasConcept C2779591629 @default.
• W2022278218 hasConcept C2779888176 @default.
• W2022278218 hasConcept C2780771799 @default.
• W2022278218 hasConcept C2908560794 @default.
• W2022278218 hasConcept C2908929049 @default.
• W2022278218 hasConcept C55493867 @default.
• W2022278218 hasConcept C71924100 @default.
• W2022278218 hasConcept C84393581 @default.
• W2022278218 hasConcept C98274493 @default.
• W2022278218 hasConceptScore W2022278218C123915805 @default.
• W2022278218 hasConceptScore W2022278218C126322002 @default.
• W2022278218 hasConceptScore W2022278218C134018914 @default.
• W2022278218 hasConceptScore W2022278218C170493617 @default.
• W2022278218 hasConceptScore W2022278218C181199279 @default.
• W2022278218 hasConceptScore W2022278218C185592680 @default.
• W2022278218 hasConceptScore W2022278218C198710026 @default.
• W2022278218 hasConceptScore W2022278218C27016395 @default.
• W2022278218 hasConceptScore W2022278218C2776820930 @default.
• W2022278218 hasConceptScore W2022278218C2776980637 @default.
• W2022278218 hasConceptScore W2022278218C2779479957 @default.
• W2022278218 hasConceptScore W2022278218C2779591629 @default.
• W2022278218 hasConceptScore W2022278218C2779888176 @default.
• W2022278218 hasConceptScore W2022278218C2780771799 @default.
• W2022278218 hasConceptScore W2022278218C2908560794 @default.
• W2022278218 hasConceptScore W2022278218C2908929049 @default.
• W2022278218 hasConceptScore W2022278218C55493867 @default.
• W2022278218 hasConceptScore W2022278218C71924100 @default.
• W2022278218 hasConceptScore W2022278218C84393581 @default.
• W2022278218 hasConceptScore W2022278218C98274493 @default.
• W2022278218 hasIssue "3" @default.
• W2022278218 hasLocation W20222782181 @default.
• W2022278218 hasLocation W20222782182 @default.
• W2022278218 hasOpenAccess W2022278218 @default.
• W2022278218 hasPrimaryLocation W20222782181 @default.
• W2022278218 hasRelatedWork W1533842627 @default.
• W2022278218 hasRelatedWork W1978888466 @default.
• W2022278218 hasRelatedWork W1982962960 @default.
• W2022278218 hasRelatedWork W1998235570 @default.

• next