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• W2022279301 abstract "The importance of cardiovascular system involvement in hyperthyroidism has been recognized for many years. In the middle-aged and elderly patient, often with mild but prolonged elevation of plasma thyroid hormones, symptoms and signs of heart failure and complicating atrial fibrillation may dominate the clinical picture and mask the more classical endocrine manifestations of the disease. Pitfalls in diagnosis and the importance of early recognition and treatment are discussed. Despite experimental evidence for a short-term isotropic action of thyroid hormone excess, clinical data support the existence of a reversible cardiomyopathy in hyperthyroidism with impaired contractile reserve. Enhanced myocardial performance at rest primarily reflects the peripheral actions of thyroid hormone excess. Most, if not all, of the cardiac abnormalities return to normal once a euthyroid state has been achieved, although atrial fibrillation may persist in a minority. Optimum treatment requires rapid and definitive antithyroid therapy, usually using a large dose of radio-iodine, and rapid control of heart failure. Systemic anti-coagulation is indicated in the presence of atrial fibrillation and should be continued until sinus rhythm has been present for at least three months, either spontaneously or after cardioversion." @default.
• W2022279301 created "2016-06-24" @default.
• W2022279301 creator A5019635638 @default.
• W2022279301 creator A5068785499 @default.
• W2022279301 date "1985-05-01" @default.
• W2022279301 modified "2023-10-18" @default.
• W2022279301 title "9 Hyperthyroid heart disease" @default.
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• W2022279301 doi "https://doi.org/10.1016/s0300-595x(85)80044-x" @default.
• W2022279301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2866053" @default.
• W2022279301 hasPublicationYear "1985" @default.
• W2022279301 type Work @default.
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