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- W2022279422 abstract "Parkinson's disease (PD) is the commonest neurodegenerative disease after Alzheimer's disease. Its lifetime risk is approximately 1:40. The major clinical features of PD are caused by the death of dopaminergic neurons in the substantia nigra pars compacta. Other areas of the brain also demonstrate neurodegeneration, e.g. the locus coeruleus and substantia innominata. Most patients with PD present in the fifth and sixth decades. The latent period for the disease onset is unknown but is likely to be around 5–7 years although this may vary according to aetiology. At present, the two main hypotheses concerning aetiology include both genetic and environmental factors. In addition, both mitochondrial dysfunction and oxidative stress are both thought to contribute to pathogenesis, and this paper will focus predominantly on the mitochondrial contribution to the aetiology and pathogenesis of PD." @default.
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- W2022279422 title "Mitochondria in the aetiology and pathogenesis of Parkinson's disease" @default.
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- W2022279422 doi "https://doi.org/10.1016/s1353-8020(99)00029-2" @default.
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