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• W2022279619 abstract "The effect of the selective dopamine receptor agonists SKF 38393 (D-1) and quinpirole (D-2) on nociception was studied in the mouse tail immersion test. The D-1 receptor agonist induced mild hyperalgesia whereas the D-2 agonist produced anticociception. Pretreatment with either the selective D-1 receptor antagonist SCH 23390 or the D-2 receptor antagonist (−)-sulpiride converted the hyperalgesia produced by the D-1 agonist into an antinociceptive response whereas the effect of the D-2 receptor agonist was significantly antagonised. The antinociceptive response of selective opioid agonists was also studied in combination with selective dopamine receptor agonists and antagonists. Sufentanil (μ-opioid) antinociception was enhanced in animals pretreated with (−)-sulpiride but not SCH 23390. In animals co-administered sufentanil with SKF 38393 there was a reduced antinociceptive effect whilst quinpirole enhanced the action of sufentanil. Likewise, antinociception induced by the κ-opioid agonist U50,488H was unaltered in animals pretreated with SCH 23390, increased by (−)-sulpiride, and reduced by SKF 38393. δ-Opioid antinociception induced by [D-Ala2,D-Leu5]enkephalin remained unmodified following pretreatment with either (−)-sulpiride or SCH 23390 but was potentiated in animals which received both the δ-agonist and the D-2 receptor agonist. It is concluded that D-2 receptor agonists not only have intrinsic antinociceptive activity, but can also potentiate opioid-induced antinociception. Similarly, dopamine D-2 receptor antagonists appear to potentiate opioid-induced antinociception in this nociceptive model." @default.
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• W2022279619 date "1989-09-01" @default.
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• W2022279619 title "Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception" @default.
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• W2022279619 doi "https://doi.org/10.1016/0014-2999(89)90794-2" @default.
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