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- W2022280636 abstract "Sorangium cellulosum, a cellulolytic myxobacterium, is capable of producing a variety of bioactive secondary metabolites. Epothilones are anti-eukaryotic secondary metabolites produced by some S. cellulosum strains. In this study, we analyzed interactions between 12 strains of S. cellulosum consisting of epothilone-producers and non-epothilone producers isolated from two distinct soil habitats. Co-cultivation on filter papers showed that different Sorangium strains inhibited one another's growth, whereas epothilone production by the producing strains changed markedly for most (73%) pairwise mixtures. Using a quantitative polymerase chain reaction, we demonstrated that the expression of epothilone biosynthetic genes in the epothilone producers typically changed significantly when these bacteria were mixed with non-producing strains. The results indicated that intraspecies interactions between different S. cellulosum strains not only inhibited the growth of partners, but also could change epothilone production." @default.
- W2022280636 created "2016-06-24" @default.
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- W2022280636 date "2013-04-18" @default.
- W2022280636 modified "2023-10-12" @default.
- W2022280636 title "Co-cultivation of<i>Sorangium cellulosum</i>strains affects cellular growth and biosynthesis of secondary metabolite epothilones" @default.
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- W2022280636 doi "https://doi.org/10.1111/1574-6941.12125" @default.
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