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- W2022280863 abstract "Abstract A mathematical model is presented for predicting the shear‐induced decrease in live cells occurring over time during tangential flow filtration. The model uses a cell death rate constant ( K ) and considers the effects of flow rate, solution viability, and filtration system volumes and dimensions. Single pass and recycle capillary experiments with solutions of high (93%), medium (87%), and low (70%) viability were run, where the maximum laminar shear stress ranged from 10– 300 Pa, to validate the model and determine cell death rate constants. The K values for the suspended CHO cells used in this research ranged from 0.06 to 12.5 s −1 . These K values increased with shear stress, as expected, and also as the solution viability decreased." @default.
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- W2022280863 date "2007-01-01" @default.
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- W2022280863 title "Modeling Shear Damage to Suspended CHO Cells during Cross-Flow Filtration" @default.
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- W2022280863 doi "https://doi.org/10.1021/bp060183e" @default.
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