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• W2022280939 abstract "The establishment of a multicellular body plan requires coordinating changes in cell adhesion and the cytoskeleton to ensure proper cell shape and position within a tissue. Cell adhesion to the extracellular matrix (ECM) via integrins plays diverse, essential roles during animal embryogenesis and therefore must be precisely regulated [1Bulgakova N.A. Klapholz B. Brown N.H. Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development.Curr. Opin. Cell Biol. 2012; 24: 702-712Crossref PubMed Scopus (43) Google Scholar]. Talin, a FERM-domain containing protein, forms a direct link between integrin adhesion receptors and the actin cytoskeleton and is an important regulator of integrin function [2Critchley D.R. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.Annu Rev Biophys. 2009; 38: 235-254Crossref PubMed Scopus (213) Google Scholar]. Similar to other FERM proteins, talin makes an intramolecular interaction that could autoinhibit its activity [3Tepass U. FERM proteins in animal morphogenesis.Curr. Opin. Genet. Dev. 2009; 19: 357-367Crossref PubMed Scopus (71) Google Scholar, 4Goksoy E. Ma Y.Q. Wang X. Kong X. Perera D. Plow E.F. Qin J. Structural basis for the autoinhibition of talin in regulating integrin activation.Mol. Cell. 2008; 31: 124-133Abstract Full Text Full Text PDF PubMed Scopus (197) Google Scholar, 5Goult B.T. Bate N. Anthis N.J. Wegener K.L. Gingras A.R. Patel B. Barsukov I.L. Campbell I.D. Roberts G.C. Critchley D.R. The structure of an interdomain complex that regulates talin activity.J. Biol. Chem. 2009; 284: 15097-15106Crossref PubMed Scopus (102) Google Scholar, 6Song X. Yang J. Hirbawi J. Ye S. Perera H.D. Goksoy E. Dwivedi P. Plow E.F. Zhang R. Qin J. A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion.Cell Res. 2012; 22: 1533-1545Crossref PubMed Scopus (78) Google Scholar]. However, the functional consequence of such an interaction has not been previously explored in vivo. Here, we demonstrate that targeted disruption of talin autoinhibition gives rise to morphogenetic defects during fly development and specifically that dorsal closure (DC), a process that resembles wound healing, is delayed. Impairment of autoinhibition leads to reduced talin turnover at and increased talin and integrin recruitment to sites of integrin-ECM attachment. Finally, we present evidence that talin autoinhibition is regulated by Rap1-dependent signaling. Based on our data, we propose that talin autoinhibition provides a switch for modulating adhesion turnover and adhesion stability that is essential for morphogenesis." @default.
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• W2022280939 date "2013-09-01" @default.
• W2022280939 modified "2023-09-27" @default.
• W2022280939 title "Talin Autoinhibition Is Required for Morphogenesis" @default.
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• W2022280939 doi "https://doi.org/10.1016/j.cub.2013.07.054" @default.
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