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• W2022282624 endingPage "2173" @default.
• W2022282624 startingPage "2167" @default.
• W2022282624 abstract "Thromboxane A2 (TXA2) receptor-mediated signal transduction was investigated in 1321N1 human astrocytoma cells. 9,11-Epithio-11,12-methano-TXA2 (STA2), a TXA2 receptor agonist, induced Ca2+ mobilization and phosphoinositide hydrolysis in a concentration-dependent manner. These responses were inhibited by treatment with U73122, an inhibitor of phosphatidylinositol-specific phospholipase C, or by culturing in 0.5% fetal calf serum containing 0.5 mM dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP) for 2 days. However, the dbcAMP treatment augmented the TXA2 receptor-mediated phosphorylation of mitogen-activated protein kinase (MAPK). These results were confirmed by a functional MAPK assay measuring the incorporation of 32P into the MAPK substrate peptide. The TXA2 receptor-mediated MAPK activation was inhibited by SQ29548, a TXA2 receptor antagonist, and GF109203X, an inhibitor of protein kinase C. Although U73122 did not inhibit or only slightly inhibited the activation of MAPK, D-609, an inhibitor of phosphatidylcholine-specific phospholipase C, potently attenuated the activation in a concentration-dependent manner. Furthermore, STA2 accelerated the release of [3H]choline metabolites from the cells prelabeled with [3H]choline chloride. This release was inhibited by treatment with D-609. These results suggest that phosphatidylcholine-specific phospholipase C and protein kinase C, but not phosphatidylinositol-specific phospholipase C, are involved in TXA2 receptor-mediated MAPK activation in 1321N1 human astrocytoma cells." @default.
• W2022282624 created "2016-06-24" @default.
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• W2022282624 date "2008-07-30" @default.
• W2022282624 modified "2023-10-13" @default.
• W2022282624 title "Involvement of Phosphatidylcholine-Specific Phospholipase C in Thromboxane A2-Induced Activation of Mitogen-Activated Protein Kinase in Astrocytoma Cells" @default.
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• W2022282624 doi "https://doi.org/10.1046/j.1471-4159.2000.0742167.x" @default.
• W2022282624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10800962" @default.
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