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- W2022283141 abstract "We assessed the release of creatine kinase MB as both mass and activity during the postoperative period following cardiac surgery. CK-MB mass was determined by enzyme immunoassay using reagents obtained from Hybritech. CK-MB activity was determined both by agarose electrophoresis and by an immunochemical method. Fifty-five patients who underwent coronary artery bypass surgery and 52 control subjects who had orthopedic surgery were selected for study. Serial serum samples were collected following surgery and total LD, CK, AST, LD-1, CK-MB mass, and CK-MB activity determined. Results were compared to each other and to surgical parameters. All patients exhibited significant CK-MB mass and activity after surgery and peak serum levels were 6–94 μg/L and 12–84 U/L, respectively. CK-MB mass correlated with CK-MB activity on paired samples (r = 0.94). Total AST and CK activities correlated with CK-MB mass (r = 0.60, and 0.63, respectively). Peak levels of CK-MB mass correlated significantly with peak MB activity (r = 0.88), peak LD-1 (r = 0.62), peak AST (r = 0.71), and time on pump (r = 0.54). Similar correlations were also seen between peak CK-MB activity and these parameters. No relationship could be identified between extent of CK-MB mass release and number of grafts, degree of hypothermia, or minimum PaO2. The time course of CK-MB mass release exhibited 85% concordance with CK-MB activity. Two patients suffered a perioperative MI and were characterized by peak CK-MB mass levels greater than 70 μg/L and a “flipped” LD. We conclude that CK-MB release following cardiac surgery may be monitored as CK-MB mass or activity, in that both provide essentially the same information." @default.
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- W2022283141 date "1987-10-01" @default.
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- W2022283141 title "Changes in serum CK-MB mass after coronary artery bypass surgery" @default.
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- W2022283141 doi "https://doi.org/10.1016/s0009-9120(87)80082-6" @default.
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