FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022284346> ?p ?o ?g. }

• W2022284346 endingPage "628" @default.
• W2022284346 startingPage "621" @default.
• W2022284346 abstract "Cardiac ischemia and anoxia induce massive norepinephrine (NE) release, which is mediated by a reverse operation of uptake-1 and can be suppressed by uptake-1 inhibitors. We studied effects of uptake-1 inhibitors on incidence of ventricular fibrillation (VF%) and myocardial contracture in perfused rat hearts under ischemic or anoxic conditions. NE release occurred in hearts during ischemia or anoxia and was largely inhibited by desipramine, imipramine, and cocaine. The generation of inositol 1,4,5-trisphosphate (InsP3) during reperfusion also was abolished by desipramine. During anoxia/reoxygenation, VF (93 and 71%, respectively) and myocardial contracture occurred and were significantly inhibited by desipramine and by NE depletion. Regional ischemia and reperfusion induced high VF% (86 and 100%, respectively), which was reduced or abolished by desipramine and imipramine at 0.03 and 0.3 microM. During the ischemic phase, cocaine was similarly antiarrhythmic, as was a combination of timolol and prazosin, but NE depletion was not. In NE-depleted hearts, cocaine or the combination of timolol and prazosin showed limited effect on VF%, whereas both desipramine and imipramine abolished VF. In anesthetized rats in vivo, ischemic VF% was reduced by desipramine (30 vs. 92%; p < 0.01). In conclusion, uptake-1 inhibitors protect hearts against ischemia/reperfusion- and anoxia/reoxygenation-induced arrhythmias, partly because of the inhibition of locally mediated NE release. Other actions of desipramine and imipramine may contribute to the overall efficacy." @default.
• W2022284346 created "2016-06-24" @default.
• W2022284346 creator A5011375886 @default.
• W2022284346 creator A5053452403 @default.
• W2022284346 creator A5058019993 @default.
• W2022284346 creator A5075494494 @default.
• W2022284346 creator A5082586880 @default.
• W2022284346 date "1998-10-01" @default.
• W2022284346 modified "2023-10-07" @default.
• W2022284346 title "Protection of Neuronal Uptake-1 Inhibitors in Ischemic and Anoxic Hearts by Norepinephrine-Dependent and -Independent Mechanisms" @default.
• W2022284346 cites W1966659841 @default.
• W2022284346 cites W1970817874 @default.
• W2022284346 cites W1982714120 @default.
• W2022284346 cites W1983307558 @default.
• W2022284346 cites W1988833283 @default.
• W2022284346 cites W1992856211 @default.
• W2022284346 cites W1992970653 @default.
• W2022284346 cites W2003900726 @default.
• W2022284346 cites W2028821720 @default.
• W2022284346 cites W2032088606 @default.
• W2022284346 cites W2032665945 @default.
• W2022284346 cites W2046660833 @default.
• W2022284346 cites W2047563687 @default.
• W2022284346 cites W2048867237 @default.
• W2022284346 cites W2055582779 @default.
• W2022284346 cites W2063705515 @default.
• W2022284346 cites W2075001763 @default.
• W2022284346 cites W2084926943 @default.
• W2022284346 cites W2085723858 @default.
• W2022284346 cites W2088392419 @default.
• W2022284346 cites W2113950363 @default.
• W2022284346 cites W2133488495 @default.
• W2022284346 cites W2139603464 @default.
• W2022284346 cites W2144633996 @default.
• W2022284346 cites W2149757602 @default.
• W2022284346 cites W2155502740 @default.
• W2022284346 cites W2401594906 @default.
• W2022284346 cites W2410716344 @default.
• W2022284346 cites W2835846723 @default.
• W2022284346 doi "https://doi.org/10.1097/00005344-199810000-00015" @default.
• W2022284346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9781931" @default.
• W2022284346 hasPublicationYear "1998" @default.
• W2022284346 type Work @default.
• W2022284346 sameAs 2022284346 @default.
• W2022284346 citedByCount "19" @default.
• W2022284346 countsByYear W20222843462012 @default.
• W2022284346 countsByYear W20222843462015 @default.
• W2022284346 countsByYear W20222843462016 @default.
• W2022284346 countsByYear W20222843462018 @default.
• W2022284346 countsByYear W20222843462020 @default.
• W2022284346 crossrefType "journal-article" @default.
• W2022284346 hasAuthorship W2022284346A5011375886 @default.
• W2022284346 hasAuthorship W2022284346A5053452403 @default.
• W2022284346 hasAuthorship W2022284346A5058019993 @default.
• W2022284346 hasAuthorship W2022284346A5075494494 @default.
• W2022284346 hasAuthorship W2022284346A5082586880 @default.
• W2022284346 hasBestOaLocation W20222843461 @default.
• W2022284346 hasConcept C126322002 @default.
• W2022284346 hasConcept C134018914 @default.
• W2022284346 hasConcept C142724271 @default.
• W2022284346 hasConcept C170493617 @default.
• W2022284346 hasConcept C178790620 @default.
• W2022284346 hasConcept C185592680 @default.
• W2022284346 hasConcept C204787440 @default.
• W2022284346 hasConcept C2776885963 @default.
• W2022284346 hasConcept C2778514916 @default.
• W2022284346 hasConcept C2779133857 @default.
• W2022284346 hasConcept C2779145073 @default.
• W2022284346 hasConcept C2779177272 @default.
• W2022284346 hasConcept C2780250439 @default.
• W2022284346 hasConcept C2780648677 @default.
• W2022284346 hasConcept C2781005686 @default.
• W2022284346 hasConcept C2781161787 @default.
• W2022284346 hasConcept C42219234 @default.
• W2022284346 hasConcept C513476851 @default.
• W2022284346 hasConcept C537181965 @default.
• W2022284346 hasConcept C541997718 @default.
• W2022284346 hasConcept C71924100 @default.
• W2022284346 hasConcept C98274493 @default.
• W2022284346 hasConceptScore W2022284346C126322002 @default.
• W2022284346 hasConceptScore W2022284346C134018914 @default.
• W2022284346 hasConceptScore W2022284346C142724271 @default.
• W2022284346 hasConceptScore W2022284346C170493617 @default.
• W2022284346 hasConceptScore W2022284346C178790620 @default.
• W2022284346 hasConceptScore W2022284346C185592680 @default.
• W2022284346 hasConceptScore W2022284346C204787440 @default.
• W2022284346 hasConceptScore W2022284346C2776885963 @default.
• W2022284346 hasConceptScore W2022284346C2778514916 @default.
• W2022284346 hasConceptScore W2022284346C2779133857 @default.
• W2022284346 hasConceptScore W2022284346C2779145073 @default.
• W2022284346 hasConceptScore W2022284346C2779177272 @default.
• W2022284346 hasConceptScore W2022284346C2780250439 @default.
• W2022284346 hasConceptScore W2022284346C2780648677 @default.
• W2022284346 hasConceptScore W2022284346C2781005686 @default.
• W2022284346 hasConceptScore W2022284346C2781161787 @default.
• W2022284346 hasConceptScore W2022284346C42219234 @default.
• W2022284346 hasConceptScore W2022284346C513476851 @default.
• W2022284346 hasConceptScore W2022284346C537181965 @default.

• next