FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022285397> ?p ?o ?g. }

• W2022285397 endingPage "114" @default.
• W2022285397 startingPage "105" @default.
• W2022285397 abstract "The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of CIP2A in cancer progression is still poorly understood. To uncover the underlying mechanism of CIP2A-mediated cell proliferation, we implemented a two-dimensional electrophoresis (2DE)-based proteomic approach to examine lung cancer cell H1299 with and without CIP2A. We found 47 proteins differentially expressed where 19 proteins were upregulated and 28 proteins were downregulated. These were categorized into functional groups such as metabolism (25%), transcriptional and translational control (23%), and the signaling pathway and protein degradation (20%). On one hand, we validate our proteomic work by measuring the metabolic change. The knockdown of CIP2A decreased the expression of LDH-A as well as the enzymatic activity, accompanying with a decreased lactate production, an increased NADH/NAD+ ratio and ROS production. On the other hand, we found that CIP2A may regulate CREB activity through bioinformatics analysis. Our following experiments showed that, CIP2A positively regulated the phosphorylation of CREB in response to the serum treatment. Therefore, our proteomic study suggested that CIP2A mediates cancer progression through the metabolic pathway and intracellular signaling cascade." @default.
• W2022285397 created "2016-06-24" @default.
• W2022285397 creator A5003794725 @default.
• W2022285397 creator A5040084135 @default.
• W2022285397 creator A5050817098 @default.
• W2022285397 creator A5061529999 @default.
• W2022285397 creator A5075135195 @default.
• W2022285397 date "2015-01-01" @default.
• W2022285397 modified "2023-09-30" @default.
• W2022285397 title "CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer" @default.
• W2022285397 cites W1964720486 @default.
• W2022285397 cites W1971212979 @default.
• W2022285397 cites W1972236331 @default.
• W2022285397 cites W1972980414 @default.
• W2022285397 cites W1973931828 @default.
• W2022285397 cites W1975757584 @default.
• W2022285397 cites W1975854213 @default.
• W2022285397 cites W1981438408 @default.
• W2022285397 cites W1985353658 @default.
• W2022285397 cites W1997817236 @default.
• W2022285397 cites W2016278956 @default.
• W2022285397 cites W2024657158 @default.
• W2022285397 cites W2032791659 @default.
• W2022285397 cites W2037657103 @default.
• W2022285397 cites W2046176730 @default.
• W2022285397 cites W2047117908 @default.
• W2022285397 cites W2055038535 @default.
• W2022285397 cites W2065260669 @default.
• W2022285397 cites W2065297569 @default.
• W2022285397 cites W2076912135 @default.
• W2022285397 cites W2079759990 @default.
• W2022285397 cites W2083459920 @default.
• W2022285397 cites W2088359631 @default.
• W2022285397 cites W2091361223 @default.
• W2022285397 cites W2121418514 @default.
• W2022285397 cites W2122381729 @default.
• W2022285397 cites W2132834292 @default.
• W2022285397 cites W2134913638 @default.
• W2022285397 cites W2136347558 @default.
• W2022285397 cites W2140261762 @default.
• W2022285397 cites W2142296555 @default.
• W2022285397 cites W2143786004 @default.
• W2022285397 cites W2147023594 @default.
• W2022285397 cites W2157561719 @default.
• W2022285397 cites W2163471981 @default.
• W2022285397 cites W2167974691 @default.
• W2022285397 cites W2169449015 @default.
• W2022285397 cites W2315492970 @default.
• W2022285397 doi "https://doi.org/10.1039/c4mb00513a" @default.
• W2022285397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4409429" @default.
• W2022285397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25325377" @default.
• W2022285397 hasPublicationYear "2015" @default.
• W2022285397 type Work @default.
• W2022285397 sameAs 2022285397 @default.
• W2022285397 citedByCount "14" @default.
• W2022285397 countsByYear W20222853972015 @default.
• W2022285397 countsByYear W20222853972016 @default.
• W2022285397 countsByYear W20222853972017 @default.
• W2022285397 countsByYear W20222853972018 @default.
• W2022285397 countsByYear W20222853972019 @default.
• W2022285397 countsByYear W20222853972021 @default.
• W2022285397 countsByYear W20222853972023 @default.
• W2022285397 crossrefType "journal-article" @default.
• W2022285397 hasAuthorship W2022285397A5003794725 @default.
• W2022285397 hasAuthorship W2022285397A5040084135 @default.
• W2022285397 hasAuthorship W2022285397A5050817098 @default.
• W2022285397 hasAuthorship W2022285397A5061529999 @default.
• W2022285397 hasAuthorship W2022285397A5075135195 @default.
• W2022285397 hasBestOaLocation W20222853972 @default.
• W2022285397 hasConcept C104317684 @default.
• W2022285397 hasConcept C11960822 @default.
• W2022285397 hasConcept C121608353 @default.
• W2022285397 hasConcept C127561419 @default.
• W2022285397 hasConcept C1629964 @default.
• W2022285397 hasConcept C178666793 @default.
• W2022285397 hasConcept C181912034 @default.
• W2022285397 hasConcept C389152 @default.
• W2022285397 hasConcept C502942594 @default.
• W2022285397 hasConcept C54355233 @default.
• W2022285397 hasConcept C55493867 @default.
• W2022285397 hasConcept C62112901 @default.
• W2022285397 hasConcept C86339819 @default.
• W2022285397 hasConcept C86803240 @default.
• W2022285397 hasConcept C95444343 @default.
• W2022285397 hasConcept C96232424 @default.
• W2022285397 hasConceptScore W2022285397C104317684 @default.
• W2022285397 hasConceptScore W2022285397C11960822 @default.
• W2022285397 hasConceptScore W2022285397C121608353 @default.
• W2022285397 hasConceptScore W2022285397C127561419 @default.
• W2022285397 hasConceptScore W2022285397C1629964 @default.
• W2022285397 hasConceptScore W2022285397C178666793 @default.
• W2022285397 hasConceptScore W2022285397C181912034 @default.
• W2022285397 hasConceptScore W2022285397C389152 @default.
• W2022285397 hasConceptScore W2022285397C502942594 @default.
• W2022285397 hasConceptScore W2022285397C54355233 @default.
• W2022285397 hasConceptScore W2022285397C55493867 @default.
• W2022285397 hasConceptScore W2022285397C62112901 @default.
• W2022285397 hasConceptScore W2022285397C86339819 @default.

• next