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• W2022286218 endingPage "210" @default.
• W2022286218 startingPage "204" @default.
• W2022286218 abstract "► We model intra-abdominal hypertension by helium pneumoperitoneum in rats. ► Intra-abdominal pressure reduces respiratory system compliance. ► PEEP counterbalances increased intra-abdominal pressure during mechanical ventilation. ► The analysis of intratidal compliance could be helpful for guiding the PEEP. We investigated the effects of intra-abdominal pressure on respiratory system compliance at different PEEP levels. 20 ventilated rats underwent four pressure levels (7, 9, 11, 13 mmHg) of helium pneumoperitoneum and were allocated to one of the four PEEP groups (0, 3, 6 and 9 cmH 2 O). From the expiratory pressure–volume curve the mathematical inflection point (MIP) was calculated. Volume-dependent compliance was analyzed using the SLICE-method. MIP-pressure correlated to the intra-abdominal pressure ( r 2 = 0.94, p < 0.001). Peak inspiratory pressure increased with intra-abdominal pressure, and was lower after recruitment-maneuvers ( p < 0.001). The compliance gain following recruitment-maneuvers depended on PEEP, intra-abdominal pressure and intratidal volume (all p < 0.001). Mean arterial pressure was independent of PEEP ( p = 0.068) and intra-abdominal pressure ( p = 0.293). Volume-dependent compliance courses varied according to PEEP and intra-abdominal pressure. The level of intra-abdominal pressure alters respiratory system mechanics in healthy lungs. Intratidal compliance can be used to guide the PEEP adjustment in intra-abdominal hypertension. If counterbalanced by PEEP, elevated intra-abdominal pressure has no negative effects on oxygenation or hemodynamics." @default.
• W2022286218 created "2016-06-24" @default.
• W2022286218 creator A5010953827 @default.
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• W2022286218 date "2012-03-01" @default.
• W2022286218 modified "2023-09-24" @default.
• W2022286218 title "Effects of intra-abdominal pressure on respiratory system mechanics in mechanically ventilated rats" @default.
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• W2022286218 doi "https://doi.org/10.1016/j.resp.2011.11.007" @default.
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