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- W2022286303 abstract "Here we report a series of 2-aryl-3-amino-1,4-naphthoquinones that generated reactive oxygen species (ROS) such as superoxide and hydrogen peroxide upon incubation in pH 7.4 under ambient aerobic conditions. ROS generation from these compounds was sensitive to structural modifications at the 3-amino position and a 2-aryl substituent promoted ROS generation. A number of these compounds were found to induce DNA damage in the presence of Cu(II) without any added reducing agent. Our data suggests that 2-aryl-3-amino-1,4-naphthoquinones' propensity to produce ROS correlated well with its DNA damage inducing ability. 2-Phenyl-3-pyrrolid-1-yl-1,4-naphthoquinone (22) was found to damage DNA at 1 μM suggesting that these compounds may have therapeutic relevance in targeting cancers which over-express Cu(II)." @default.
- W2022286303 created "2016-06-24" @default.
- W2022286303 creator A5036424513 @default.
- W2022286303 creator A5063685954 @default.
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- W2022286303 date "2012-06-01" @default.
- W2022286303 modified "2023-10-16" @default.
- W2022286303 title "Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones" @default.
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- W2022286303 doi "https://doi.org/10.1016/j.bmcl.2012.04.009" @default.
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