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- W2022287079 abstract "<i>Background:</i> Five patients underwent magnetic resonance imaging (MRI) following MRI-guided stereotactic bilateral anterior capsulotomy to detect lesion-related anatomic changes. <i>Methods:</i> Five disabled and treatment-resistant patients with major depression (n = 4) and obsessive-compulsive disorder (n = 1) underwent stereotactic bilateral anterior capsulotomy. All patients had postoperative MRI at 2 months and at 1–4 years after surgery. An additional patient who had a pure motor deficit following a spontaneous basal ganglia hemorrhagic stroke was imaged as a comparator. <i>Results:</i> The 2-month postcapsulotomy MRI showed a previously undescribed increase in T<sub>1</sub>-weighted signal within similar neural pathways for each patient. These pathways showed no changes in T<sub>2</sub>-weighted or fluid-attenuated inversion recovery sequences. The signal changes are different from the expected changes associated with anterograde Wallerian degeneration and identify retrograde changes in the proximal segment of the interrupted axon. <i>Conclusion:</i> Previously undescribed T<sub>1</sub>-weighted signal alterations following stereotactic surgery identify retrograde non-Wallerian changes in interrupted axons and provide a new method in identifying and tracing lesioned pathways." @default.
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- W2022287079 date "2006-01-01" @default.
- W2022287079 modified "2023-09-26" @default.
- W2022287079 title "Tract Identification by Novel MRI Signal Changes following Stereotactic Anterior Capsulotomy" @default.
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