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- W2022287325 abstract "Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family that functions as an endocrine factor. In obese animals, elevation of plasma FGF21 levels by either pharmacological or genetic approaches reduces body weight, decreases hyperglycemia and hyperlipidemia, alleviates fatty liver and increases insulin sensitivity. FGF21 exerts its pleiotropic metabolic effects through its actions on multiple targets, including adipose tissue, liver, brain and pancreas. The expression of FGF21 is under the control of both peroxisome proliferator-activated receptor gamma (PPARγ) and peroxisome proliferator-activated receptor alpha (PPARα). A growing body of evidence suggests that the metabolic benefits of these two nuclear receptors are mediated in part by induction of FGF21. In humans, plasma levels of FGF21 are elevated in obese subjects and patients with type 2 diabetes, but are reduced in patients with autoimmune diabetes. This review summarizes recent advances in understanding the physiological roles of FGF21 and the molecular pathways underlying its actions, and also discusses the future prospective of developing FGF21 or its agonists as therapeutic agents for obesity-related medical complications." @default.
- W2022287325 created "2016-06-24" @default.
- W2022287325 creator A5013531203 @default.
- W2022287325 creator A5031014820 @default.
- W2022287325 creator A5079594267 @default.
- W2022287325 creator A5082241479 @default.
- W2022287325 date "2012-08-01" @default.
- W2022287325 modified "2023-10-11" @default.
- W2022287325 title "Metabolic actions of FGF21: molecular mechanisms and therapeutic implications" @default.
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- W2022287325 doi "https://doi.org/10.1016/j.apsb.2012.06.011" @default.
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