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• W2022287810 abstract "Background: Low bone mineral density (BMD) has been reported in HIV+ women, but less is known about the longitudinal evolution of BMD and fracture incidence. Methods: In 100 HIV+ and 68 HIV− premenopausal women in the Women's Interagency HIV Study, BMD was measured by dual energy x-ray absorptiometry at the femoral neck (FN) and lumbar spine (LS) at index visit and after a median of 2.5 years. Results: In HIV+ women, BMD at index visit was normal but 5% lower at the LS and FN than in HIV− women. Annual percent decrease in BMD did not differ between HIV+ and HIV− women at the LS (−0.8% ± 0.2% vs −0.4% ± 0.2%, P = 0.20) or FN (−0.8% ± 0.3% vs −0.6% ± 0.3%, P = 0.56) and remained similar after adjustment for age, weight, and BMD at index visit. Among HIV+ women, bone loss was associated with vitamin D deficiency and opiate use but not with use or class of antiretrovirals. Incidence of self-reported fracture was 0.74 per 100 person-years in HIV+ women and similar in HIV− women. Conclusions: In premenopausal HIV+ women, index BMD was lower than comparable HIV− women; however, rates of bone loss at the LS and FN were similar over 2.5 years of observation, irrespective of antiretroviral therapy." @default.
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• W2022287810 date "2010-02-01" @default.
• W2022287810 modified "2023-09-26" @default.
• W2022287810 title "Short-Term Bone Loss in HIV-Infected Premenopausal Women" @default.
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• W2022287810 doi "https://doi.org/10.1097/qai.0b013e3181bf6471" @default.
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