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- W2022288558 abstract "Natural bovine seminal RNase possesses a potent antitumor action. We have mutagenized monomeric bovine pancreatic RNase A, devoid of any cytotoxic action, to insert residues present at corresponding positions in the subunit of dimeric, antitumor, seminal RNase. Like naturally dimeric seminal RNase, the mutant dimeric RNase display selective toxicity for malignant cells, which is absent in the monomeric mutants." @default.
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- W2022288558 date "1998-11-01" @default.
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- W2022288558 title "Protein engineering of ribonucleases" @default.
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- W2022288558 doi "https://doi.org/10.1016/s0300-9084(00)88887-2" @default.
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