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• W2022289327 abstract "Cell-substrate and cell-cell adhesion of neutrophils has been found to slow down the calcium ionophore A23187-induced synthesis of 5-lipoxygenase (5-LO) metabolites of arachidonic acid. Addition of the exogenous substrate, arachidonic acid (AA), together with A23187, resulted in the enhanced production of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) by adherent neutrophils in comparison with those by the cells in suspension. We observed also the enhanced production of 5-LO metabolites in attached cells when we stimulated the cells by the combined action of phorbol 12-myristate 13-acetate (PMA) and A23187. Thus, the adhesion to solid substrate and to other cells, an important regulatory factor for the activity of many cells, is a powerful regulator of leukotriene production by neutrophils." @default.
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• W2022289327 date "1993-12-27" @default.
• W2022289327 modified "2023-09-27" @default.
• W2022289327 title "Adhesive interactions of neutrophils and leukotriene synthesis" @default.
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• W2022289327 doi "https://doi.org/10.1016/0014-5793(93)80802-2" @default.
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