FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022290870> ?p ?o ?g. }

• W2022290870 endingPage "665" @default.
• W2022290870 startingPage "657" @default.
• W2022290870 abstract "Neurochemical studies performed in vivo have suggested that serotonin-containing and -synthesizing nerves, originating in the raphe nuclei, directly innervate pial blood vessels. Nerve fibres of these vessels have been shown by immunocytochemistry to contain tryptophan hydroxylase (the rate-limiting enzyme of serotonin synthesis) but no serotonin. The present study examines this contradiction by measuring in vitro the tryptophan hydroxylase activity of rat cerebral vessels and femoral arteries (which also contain tryptophan hydroxylase-immunopositive nerves), and comparing them to the tryptophan hydroxylase activity of the rat pineal body, raphe nuclei and brain cortex under identical conditions. Oxygenated incubation solutions contained either [14C]- or cold L-tryptophan (2 x 10(-5) to 5 x 10(-4) M) and NSD-1015 (3-hydroxybenzylhydrazine) which inhibits the decarboxylation of 5-hydroxytryptophan, the second step of serotonin synthesis. Tissue fragments were incubated for 35-60 min. High-performance liquid chromatography (on tissue extracts and incubation solutions) as well as determination of 14C activity in the 5-hydroxytryptophan fraction of elution from tissue extracts showed that the pineal body, the raphe nuclei and cortical slices synthesize various amounts of 5-hydroxytryptophan under our experimental conditions. All these tissues contained serotonin. Femoral arteries, but not cerebral vessels, also contained small amounts of serotonin stored before incubation, probably in mast cells. In contrast to brain tissues, no measurable amounts of cold or [14C]5-hydroxytryptophan were found in cerebral blood vessel and femoral artery extracts or incubation solutions. Under identical experimental conditions, sympathetic nerves of both types of vessels were able to synthesize large amounts of L-DOPA when incubation solutions contained L-tyrosine instead of L-tryptophan.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2022290870 created "2016-06-24" @default.
• W2022290870 creator A5007324451 @default.
• W2022290870 creator A5028667110 @default.
• W2022290870 creator A5030323385 @default.
• W2022290870 creator A5059664963 @default.
• W2022290870 creator A5074600948 @default.
• W2022290870 creator A5046009744 @default.
• W2022290870 date "1993-02-01" @default.
• W2022290870 modified "2023-10-18" @default.
• W2022290870 title "Absence of serotonergic innervation from raphe nuclei in rat cerebral blood vessels—II. Lack of tryptophan hydroxylase activityin vitro" @default.
• W2022290870 cites W1520339572 @default.
• W2022290870 cites W1571821264 @default.
• W2022290870 cites W16530239 @default.
• W2022290870 cites W1737363491 @default.
• W2022290870 cites W1972937456 @default.
• W2022290870 cites W1973776833 @default.
• W2022290870 cites W1973828234 @default.
• W2022290870 cites W1979123999 @default.
• W2022290870 cites W1995296537 @default.
• W2022290870 cites W2007468386 @default.
• W2022290870 cites W2007748528 @default.
• W2022290870 cites W2011757416 @default.
• W2022290870 cites W2017745936 @default.
• W2022290870 cites W2020979475 @default.
• W2022290870 cites W2024400590 @default.
• W2022290870 cites W2024491673 @default.
• W2022290870 cites W2028029052 @default.
• W2022290870 cites W2028674543 @default.
• W2022290870 cites W2034484380 @default.
• W2022290870 cites W2041407419 @default.
• W2022290870 cites W2047079279 @default.
• W2022290870 cites W2049809715 @default.
• W2022290870 cites W2050455551 @default.
• W2022290870 cites W2050501358 @default.
• W2022290870 cites W2064156244 @default.
• W2022290870 cites W2068535052 @default.
• W2022290870 cites W2083906347 @default.
• W2022290870 cites W2086751397 @default.
• W2022290870 cites W2089167541 @default.
• W2022290870 cites W2089757878 @default.
• W2022290870 cites W2102319089 @default.
• W2022290870 cites W2107839689 @default.
• W2022290870 cites W2125417957 @default.
• W2022290870 cites W227535556 @default.
• W2022290870 cites W4239496568 @default.
• W2022290870 doi "https://doi.org/10.1016/0306-4522(93)90414-b" @default.
• W2022290870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7680792" @default.
• W2022290870 hasPublicationYear "1993" @default.
• W2022290870 type Work @default.
• W2022290870 sameAs 2022290870 @default.
• W2022290870 citedByCount "12" @default.
• W2022290870 crossrefType "journal-article" @default.
• W2022290870 hasAuthorship W2022290870A5007324451 @default.
• W2022290870 hasAuthorship W2022290870A5028667110 @default.
• W2022290870 hasAuthorship W2022290870A5030323385 @default.
• W2022290870 hasAuthorship W2022290870A5046009744 @default.
• W2022290870 hasAuthorship W2022290870A5059664963 @default.
• W2022290870 hasAuthorship W2022290870A5074600948 @default.
• W2022290870 hasConcept C105702510 @default.
• W2022290870 hasConcept C126322002 @default.
• W2022290870 hasConcept C134018914 @default.
• W2022290870 hasConcept C170493617 @default.
• W2022290870 hasConcept C185592680 @default.
• W2022290870 hasConcept C25642318 @default.
• W2022290870 hasConcept C2775864247 @default.
• W2022290870 hasConcept C2775951788 @default.
• W2022290870 hasConcept C2776706248 @default.
• W2022290870 hasConcept C2777615928 @default.
• W2022290870 hasConcept C2777865548 @default.
• W2022290870 hasConcept C2779999352 @default.
• W2022290870 hasConcept C32610206 @default.
• W2022290870 hasConcept C35866371 @default.
• W2022290870 hasConcept C37000724 @default.
• W2022290870 hasConcept C515207424 @default.
• W2022290870 hasConcept C55493867 @default.
• W2022290870 hasConcept C71924100 @default.
• W2022290870 hasConcept C86803240 @default.
• W2022290870 hasConceptScore W2022290870C105702510 @default.
• W2022290870 hasConceptScore W2022290870C126322002 @default.
• W2022290870 hasConceptScore W2022290870C134018914 @default.
• W2022290870 hasConceptScore W2022290870C170493617 @default.
• W2022290870 hasConceptScore W2022290870C185592680 @default.
• W2022290870 hasConceptScore W2022290870C25642318 @default.
• W2022290870 hasConceptScore W2022290870C2775864247 @default.
• W2022290870 hasConceptScore W2022290870C2775951788 @default.
• W2022290870 hasConceptScore W2022290870C2776706248 @default.
• W2022290870 hasConceptScore W2022290870C2777615928 @default.
• W2022290870 hasConceptScore W2022290870C2777865548 @default.
• W2022290870 hasConceptScore W2022290870C2779999352 @default.
• W2022290870 hasConceptScore W2022290870C32610206 @default.
• W2022290870 hasConceptScore W2022290870C35866371 @default.
• W2022290870 hasConceptScore W2022290870C37000724 @default.
• W2022290870 hasConceptScore W2022290870C515207424 @default.
• W2022290870 hasConceptScore W2022290870C55493867 @default.
• W2022290870 hasConceptScore W2022290870C71924100 @default.
• W2022290870 hasConceptScore W2022290870C86803240 @default.
• W2022290870 hasIssue "3" @default.

• next