FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022293360> ?p ?o ?g. }

• W2022293360 endingPage "15499" @default.
• W2022293360 startingPage "15494" @default.
• W2022293360 abstract "The cold and menthol receptor, TRPM8, also designated CMR1, is a member of the transient receptor potential (TRP) family of excitatory ion channels. TRPM8 is a channel activated by cold temperatures, voltage, and menthol. In this study, we characterize the cold- and voltage-induced activation of TRPM8 channel in an attempt to identify the temperature- and voltage-dependent components involved in channel activation. Under equilibrium conditions, decreasing temperature has two effects. ( i ) It shifts the normalized conductance vs. voltage curves toward the left, along the voltage axis. This effect indicates that the degree of order is higher when the channel is in the open configuration. ( ii ) It increases the maximum channel open probability, suggesting that temperature affects both voltage-dependent and -independent pathways. In the temperature range between 18°C and 25°C, large changes in enthalpy (Δ H = -112 kcal/mol) and entropy (Δ S = -384 cal/mol K) accompany the activation process. The Q 10 calculated in the same temperature range is 24. This thermodynamic analysis strongly suggests that the process of opening involves large conformational changes of the channel-forming protein. Therefore, the highly temperature-dependent transition between open and closed configurations is possible because enthalpy and entropy are both large and compensate each other. Our data also demonstrate that temperature and voltage interact allosterically to enhance channel opening." @default.
• W2022293360 created "2016-06-24" @default.
• W2022293360 creator A5029670158 @default.
• W2022293360 creator A5039029363 @default.
• W2022293360 creator A5042230025 @default.
• W2022293360 date "2004-10-18" @default.
• W2022293360 modified "2023-10-03" @default.
• W2022293360 title "Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8" @default.
• W2022293360 cites W1495409864 @default.
• W2022293360 cites W1511198581 @default.
• W2022293360 cites W1562645017 @default.
• W2022293360 cites W1579310096 @default.
• W2022293360 cites W1989585015 @default.
• W2022293360 cites W1995330222 @default.
• W2022293360 cites W2006775310 @default.
• W2022293360 cites W2014799719 @default.
• W2022293360 cites W2024984063 @default.
• W2022293360 cites W2040664792 @default.
• W2022293360 cites W2043272615 @default.
• W2022293360 cites W2052037844 @default.
• W2022293360 cites W2059742450 @default.
• W2022293360 cites W2061905631 @default.
• W2022293360 cites W2065897367 @default.
• W2022293360 cites W2066098715 @default.
• W2022293360 cites W2082523485 @default.
• W2022293360 cites W2090617423 @default.
• W2022293360 cites W2094955398 @default.
• W2022293360 cites W2098512267 @default.
• W2022293360 cites W2100241249 @default.
• W2022293360 cites W2100713606 @default.
• W2022293360 cites W2107057154 @default.
• W2022293360 cites W2118622904 @default.
• W2022293360 cites W2120229762 @default.
• W2022293360 cites W2129220462 @default.
• W2022293360 cites W2135567029 @default.
• W2022293360 cites W2136684513 @default.
• W2022293360 cites W2149397196 @default.
• W2022293360 cites W2159380625 @default.
• W2022293360 cites W2166084555 @default.
• W2022293360 cites W2166283865 @default.
• W2022293360 cites W2166797811 @default.
• W2022293360 doi "https://doi.org/10.1073/pnas.0406773101" @default.
• W2022293360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/523461" @default.
• W2022293360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15492228" @default.
• W2022293360 hasPublicationYear "2004" @default.
• W2022293360 type Work @default.
• W2022293360 sameAs 2022293360 @default.
• W2022293360 citedByCount "308" @default.
• W2022293360 countsByYear W20222933602012 @default.
• W2022293360 countsByYear W20222933602013 @default.
• W2022293360 countsByYear W20222933602014 @default.
• W2022293360 countsByYear W20222933602015 @default.
• W2022293360 countsByYear W20222933602016 @default.
• W2022293360 countsByYear W20222933602017 @default.
• W2022293360 countsByYear W20222933602018 @default.
• W2022293360 countsByYear W20222933602019 @default.
• W2022293360 countsByYear W20222933602020 @default.
• W2022293360 countsByYear W20222933602021 @default.
• W2022293360 countsByYear W20222933602022 @default.
• W2022293360 countsByYear W20222933602023 @default.
• W2022293360 crossrefType "journal-article" @default.
• W2022293360 hasAuthorship W2022293360A5029670158 @default.
• W2022293360 hasAuthorship W2022293360A5039029363 @default.
• W2022293360 hasAuthorship W2022293360A5042230025 @default.
• W2022293360 hasBestOaLocation W20222933601 @default.
• W2022293360 hasConcept C106301342 @default.
• W2022293360 hasConcept C121332964 @default.
• W2022293360 hasConcept C121932024 @default.
• W2022293360 hasConcept C155164980 @default.
• W2022293360 hasConcept C160145004 @default.
• W2022293360 hasConcept C163146387 @default.
• W2022293360 hasConcept C170493617 @default.
• W2022293360 hasConcept C178790620 @default.
• W2022293360 hasConcept C185592680 @default.
• W2022293360 hasConcept C26873012 @default.
• W2022293360 hasConcept C2780194911 @default.
• W2022293360 hasConcept C3288061 @default.
• W2022293360 hasConcept C39353612 @default.
• W2022293360 hasConcept C55493867 @default.
• W2022293360 hasConcept C97355855 @default.
• W2022293360 hasConceptScore W2022293360C106301342 @default.
• W2022293360 hasConceptScore W2022293360C121332964 @default.
• W2022293360 hasConceptScore W2022293360C121932024 @default.
• W2022293360 hasConceptScore W2022293360C155164980 @default.
• W2022293360 hasConceptScore W2022293360C160145004 @default.
• W2022293360 hasConceptScore W2022293360C163146387 @default.
• W2022293360 hasConceptScore W2022293360C170493617 @default.
• W2022293360 hasConceptScore W2022293360C178790620 @default.
• W2022293360 hasConceptScore W2022293360C185592680 @default.
• W2022293360 hasConceptScore W2022293360C26873012 @default.
• W2022293360 hasConceptScore W2022293360C2780194911 @default.
• W2022293360 hasConceptScore W2022293360C3288061 @default.
• W2022293360 hasConceptScore W2022293360C39353612 @default.
• W2022293360 hasConceptScore W2022293360C55493867 @default.
• W2022293360 hasConceptScore W2022293360C97355855 @default.
• W2022293360 hasIssue "43" @default.
• W2022293360 hasLocation W20222933601 @default.
• W2022293360 hasLocation W20222933602 @default.

• next