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- W2022295910 endingPage "1634" @default.
- W2022295910 startingPage "1623" @default.
- W2022295910 abstract "SUMMARY Addiction is a complex psychiatric disorder considered to be a disease of the brain's natural reward reinforcement system. Repeated stimulation of the`reward' pathway leads to adaptive changes in gene expression and synaptic organization that reinforce drug taking and underlie long-term changes in behaviour. The primitive nature of reward reinforcement pathways and the near universal ability of abused drugs to target the same system allow drug-associated reward and reinforcement to be studied in non-mammalian species. Zebrafish have proved to be a valuable model system for the study of vertebrate development and disease. Here we demonstrate that adult zebrafish show a dose-dependent acute conditioned place preference (CPP) reinforcement response to ethanol or nicotine. Repeated exposure of adult zebrafish to either nicotine or ethanol leads to a robust CPP response that persists following 3 weeks of abstinence and in the face of adverse stimuli, a behavioural indicator of the establishment of dependence. Microarray analysis using whole brain samples from drug-treated and control zebrafish identified 1362 genes that show a significant change in expression between control and treated individuals. Of these genes, 153 are common to both ethanol- and nicotine-treated animals. These genes include members of pathways and processes implicated in drug dependence in mammalian models, revealing conservation of neuro-adaptation pathways between zebrafish and mammals." @default.
- W2022295910 created "2016-06-24" @default.
- W2022295910 creator A5014973038 @default.
- W2022295910 creator A5015753146 @default.
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- W2022295910 creator A5058691662 @default.
- W2022295910 creator A5062299099 @default.
- W2022295910 date "2008-05-15" @default.
- W2022295910 modified "2023-10-12" @default.
- W2022295910 title "Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways" @default.
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- W2022295910 doi "https://doi.org/10.1242/jeb.014399" @default.
- W2022295910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18456890" @default.
- W2022295910 hasPublicationYear "2008" @default.