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- W2022296377 abstract "The redistribution of adenyl cyclase and of cyclic nucleotide phosphodiesterase has been examined in the chicken sciatic nerve after constriction. Over a period of 20 h the level of particle-bound adenyl cyclase in the nerve segment proximal to the constriction was increased to 266% of the control value, whereas the level of soluble phosphodiesterase was increased to 150%. Electron micrographs demonstrated packing of the intra-axonal space adjacent to the occlusion by diverse vesicular and granular structures, but little change in the contours of the axon surface membrane. The results indicate that a portion of nerve adenyl cyclase is associated with an intracellular particle, which moves from the perikaryon to the periphery. The possible relevance of these findings to the role of cyclic AMP in the release of neurotransmitters is considered." @default.
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- W2022296377 date "1971-03-01" @default.
- W2022296377 modified "2023-09-25" @default.
- W2022296377 title "Adenyl cyclase, cyclic nucleotide phosphodiesterase and axoplasmic flow" @default.
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- W2022296377 doi "https://doi.org/10.1016/s0006-8993(71)80012-4" @default.
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