FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022300249> ?p ?o ?g. }

• W2022300249 endingPage "130" @default.
• W2022300249 startingPage "121" @default.
• W2022300249 abstract "Testosterone (T) is known to masculinize the female phenotype of the liver, evidenced as up- and down-regulated expressions of male- and female-predominant genes, respectively, involved in hepatic metabolism. This study is aimed at identifying epigenetic modifications of promoters of these differently expressed genes in the liver after masculinization by T of adult female C57BL/6 mice using methylated DNA immunoprecipitation and NimbleGen microarrays. Among the 17,354 promoters examined, 82 promoters in the liver have been identified to be significantly changed by T (p < 0.05), with 47 and 35 promoters exhibiting increased and decreased DNA methylation, respectively. Most of these promoters display the changes of DNA methylation in their Ups-regions, which are between +500 and +2000 bp upstream from the transcription start site (TSS) of the genes. Less T-induced modifications have been detected in the Cor-regions of the promoters, i.e., +500 to −500 bp around the TSS. Only 13 and 7 Cor-promoters are hyper- and hypo-methylated, respectively, among which are 10 hyper- and 5 hypo-methylated promoters of genes with annotated functions. Surprisingly, the promoters are largely unmethylated in those genes whose expression has been previously found to be permanently deregulated by T in the liver, as e.g. the T-upregulated male-predominant genes Cyp7b1, Cyp2d9, Cyp4a10, Ugt2b1, Ugt2b38, Hsd3b5, Slco1a1 as well as the T-downregulated female-predominant genes Cyp2b9, Cyp2b13, Cyp3a41, Cyp3a44, Fmo3, Sult2a2, respectively. Though methylatable, the promoter DNA of Ar, Esr1, and Esr2 remained unaffected by T. However, T decreases DNA-methylation of the Cor-promoter region of Ddc encoding the AR-coactivator dopa decarboxylase. Among the identified 15 Cor-promoters of genes with annotated functions are also those of Defb43, Cst11, and Sele involved in innate immunity. Our data support the view that T may exert long-lasting epigenetic effects on functions of the liver-inherent immune system." @default.
• W2022300249 created "2016-06-24" @default.
• W2022300249 creator A5004985231 @default.
• W2022300249 creator A5026772341 @default.
• W2022300249 creator A5031761453 @default.
• W2022300249 creator A5058928863 @default.
• W2022300249 creator A5071457736 @default.
• W2022300249 creator A5072937215 @default.
• W2022300249 creator A5085321316 @default.
• W2022300249 date "2015-01-01" @default.
• W2022300249 modified "2023-10-12" @default.
• W2022300249 title "Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone" @default.
• W2022300249 cites W1591745752 @default.
• W2022300249 cites W1964011590 @default.
• W2022300249 cites W1966030580 @default.
• W2022300249 cites W1966700862 @default.
• W2022300249 cites W1967190902 @default.
• W2022300249 cites W1968248461 @default.
• W2022300249 cites W1973481320 @default.
• W2022300249 cites W1984985372 @default.
• W2022300249 cites W1986064910 @default.
• W2022300249 cites W1987557775 @default.
• W2022300249 cites W1995397347 @default.
• W2022300249 cites W1999478182 @default.
• W2022300249 cites W2009938151 @default.
• W2022300249 cites W2015258298 @default.
• W2022300249 cites W2015970925 @default.
• W2022300249 cites W2016508574 @default.
• W2022300249 cites W2019229253 @default.
• W2022300249 cites W2023767649 @default.
• W2022300249 cites W2026399748 @default.
• W2022300249 cites W2029284801 @default.
• W2022300249 cites W2033537830 @default.
• W2022300249 cites W2038394041 @default.
• W2022300249 cites W2038933398 @default.
• W2022300249 cites W2039614549 @default.
• W2022300249 cites W2040298111 @default.
• W2022300249 cites W2047712912 @default.
• W2022300249 cites W2049973318 @default.
• W2022300249 cites W2054621094 @default.
• W2022300249 cites W2060755905 @default.
• W2022300249 cites W2065651067 @default.
• W2022300249 cites W2074074395 @default.
• W2022300249 cites W2075075693 @default.
• W2022300249 cites W2077883370 @default.
• W2022300249 cites W2079298594 @default.
• W2022300249 cites W2080367498 @default.
• W2022300249 cites W2086038987 @default.
• W2022300249 cites W2087514104 @default.
• W2022300249 cites W2089284490 @default.
• W2022300249 cites W2091524315 @default.
• W2022300249 cites W2101563246 @default.
• W2022300249 cites W2105300601 @default.
• W2022300249 cites W2107038650 @default.
• W2022300249 cites W2118247434 @default.
• W2022300249 cites W2119467744 @default.
• W2022300249 cites W2121671287 @default.
• W2022300249 cites W2123032740 @default.
• W2022300249 cites W2124966147 @default.
• W2022300249 cites W2127081952 @default.
• W2022300249 cites W2128899676 @default.
• W2022300249 cites W2131836848 @default.
• W2022300249 cites W2136531196 @default.
• W2022300249 cites W2137334102 @default.
• W2022300249 cites W2142089665 @default.
• W2022300249 cites W2148300725 @default.
• W2022300249 cites W2148478555 @default.
• W2022300249 cites W2150174523 @default.
• W2022300249 cites W2151148777 @default.
• W2022300249 cites W2152633679 @default.
• W2022300249 cites W2152656267 @default.
• W2022300249 cites W2154693416 @default.
• W2022300249 cites W2160260491 @default.
• W2022300249 cites W2161250377 @default.
• W2022300249 cites W2164236134 @default.
• W2022300249 cites W2170978015 @default.
• W2022300249 cites W78683901 @default.
• W2022300249 doi "https://doi.org/10.1016/j.jsbmb.2014.11.006" @default.
• W2022300249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25448745" @default.
• W2022300249 hasPublicationYear "2015" @default.
• W2022300249 type Work @default.
• W2022300249 sameAs 2022300249 @default.
• W2022300249 citedByCount "23" @default.
• W2022300249 countsByYear W20223002492015 @default.
• W2022300249 countsByYear W20223002492016 @default.
• W2022300249 countsByYear W20223002492017 @default.
• W2022300249 countsByYear W20223002492018 @default.
• W2022300249 countsByYear W20223002492019 @default.
• W2022300249 countsByYear W20223002492020 @default.
• W2022300249 countsByYear W20223002492021 @default.
• W2022300249 countsByYear W20223002492023 @default.
• W2022300249 crossrefType "journal-article" @default.
• W2022300249 hasAuthorship W2022300249A5004985231 @default.
• W2022300249 hasAuthorship W2022300249A5026772341 @default.
• W2022300249 hasAuthorship W2022300249A5031761453 @default.
• W2022300249 hasAuthorship W2022300249A5058928863 @default.
• W2022300249 hasAuthorship W2022300249A5071457736 @default.
• W2022300249 hasAuthorship W2022300249A5072937215 @default.

• next