Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022303561> ?p ?o ?g. }
- W2022303561 endingPage "270" @default.
- W2022303561 startingPage "267" @default.
- W2022303561 abstract "In the present study, we examined the effects of acamprosate for its ability to reduce handling induced convulsions (HICs) during alcohol withdrawal. Diazepam was used as a positive control. Swiss Webster male mice received three daily IP injections of alcohol (2.5 g/kg) or alcohol (2.5 g/kg) + methylpyrazole (4-MP) (9 mg/kg). (4-MP, being an alcohol dehydrogenase inhibitor slows down the breakdown of alcohol. 4-MP in combination with alcohol exhibits a dramatic increase in blood alcohol level compared to alcohol alone). Ten hours following the last alcohol injection, the mice were picked up by the tail and examined for their seizure susceptibility (HICs). Diazepam, a benzodiazepine known to reduce seizures during alcohol withdrawal, significantly reduced these HICs at doses of 0.25, 0.5 and 1 mg/kg (p's < 0.001). Acamprosate, an anti-relapse compound used clinically in newly abstinent alcoholics, also reduced these HICs at doses of 100, 200 and 300 mg/kg (p's < 0.05). This study supports the use of acamprosate during periods of alcohol withdrawal as well as during abstinence." @default.
- W2022303561 created "2016-06-24" @default.
- W2022303561 creator A5018932316 @default.
- W2022303561 creator A5054685823 @default.
- W2022303561 creator A5056677030 @default.
- W2022303561 creator A5057131258 @default.
- W2022303561 creator A5072016667 @default.
- W2022303561 creator A5083164066 @default.
- W2022303561 date "2008-09-01" @default.
- W2022303561 modified "2023-10-16" @default.
- W2022303561 title "Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice" @default.
- W2022303561 cites W1971108844 @default.
- W2022303561 cites W1985180181 @default.
- W2022303561 cites W1991641846 @default.
- W2022303561 cites W1992093536 @default.
- W2022303561 cites W1993776646 @default.
- W2022303561 cites W1999878692 @default.
- W2022303561 cites W2005949458 @default.
- W2022303561 cites W2006954651 @default.
- W2022303561 cites W2010120512 @default.
- W2022303561 cites W2013124619 @default.
- W2022303561 cites W2013999363 @default.
- W2022303561 cites W2015207248 @default.
- W2022303561 cites W2015805931 @default.
- W2022303561 cites W2023156098 @default.
- W2022303561 cites W2032488758 @default.
- W2022303561 cites W2032681902 @default.
- W2022303561 cites W2033122986 @default.
- W2022303561 cites W2042931973 @default.
- W2022303561 cites W2043821740 @default.
- W2022303561 cites W2047829260 @default.
- W2022303561 cites W2048910098 @default.
- W2022303561 cites W2052360330 @default.
- W2022303561 cites W2053929792 @default.
- W2022303561 cites W2057137756 @default.
- W2022303561 cites W2059402504 @default.
- W2022303561 cites W2070035008 @default.
- W2022303561 cites W2080574826 @default.
- W2022303561 cites W2081524870 @default.
- W2022303561 cites W2089237550 @default.
- W2022303561 cites W2112824246 @default.
- W2022303561 cites W2124354991 @default.
- W2022303561 cites W4239843730 @default.
- W2022303561 cites W4247591891 @default.
- W2022303561 doi "https://doi.org/10.1016/j.physbeh.2008.05.020" @default.
- W2022303561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2561203" @default.
- W2022303561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18577392" @default.
- W2022303561 hasPublicationYear "2008" @default.
- W2022303561 type Work @default.
- W2022303561 sameAs 2022303561 @default.
- W2022303561 citedByCount "21" @default.
- W2022303561 countsByYear W20223035612012 @default.
- W2022303561 countsByYear W20223035612014 @default.
- W2022303561 countsByYear W20223035612015 @default.
- W2022303561 countsByYear W20223035612016 @default.
- W2022303561 countsByYear W20223035612017 @default.
- W2022303561 countsByYear W20223035612018 @default.
- W2022303561 countsByYear W20223035612019 @default.
- W2022303561 countsByYear W20223035612020 @default.
- W2022303561 countsByYear W20223035612022 @default.
- W2022303561 countsByYear W20223035612023 @default.
- W2022303561 crossrefType "journal-article" @default.
- W2022303561 hasAuthorship W2022303561A5018932316 @default.
- W2022303561 hasAuthorship W2022303561A5054685823 @default.
- W2022303561 hasAuthorship W2022303561A5056677030 @default.
- W2022303561 hasAuthorship W2022303561A5057131258 @default.
- W2022303561 hasAuthorship W2022303561A5072016667 @default.
- W2022303561 hasAuthorship W2022303561A5083164066 @default.
- W2022303561 hasBestOaLocation W20223035612 @default.
- W2022303561 hasConcept C118552586 @default.
- W2022303561 hasConcept C126322002 @default.
- W2022303561 hasConcept C170493617 @default.
- W2022303561 hasConcept C185592680 @default.
- W2022303561 hasConcept C2776175493 @default.
- W2022303561 hasConcept C2776885963 @default.
- W2022303561 hasConcept C2777010014 @default.
- W2022303561 hasConcept C2777344606 @default.
- W2022303561 hasConcept C2777972943 @default.
- W2022303561 hasConcept C2778173252 @default.
- W2022303561 hasConcept C2778186239 @default.
- W2022303561 hasConcept C2778523461 @default.
- W2022303561 hasConcept C2779436514 @default.
- W2022303561 hasConcept C2779992327 @default.
- W2022303561 hasConcept C2780161600 @default.
- W2022303561 hasConcept C2780687700 @default.
- W2022303561 hasConcept C2781066024 @default.
- W2022303561 hasConcept C42219234 @default.
- W2022303561 hasConcept C55493867 @default.
- W2022303561 hasConcept C71924100 @default.
- W2022303561 hasConcept C98274493 @default.
- W2022303561 hasConceptScore W2022303561C118552586 @default.
- W2022303561 hasConceptScore W2022303561C126322002 @default.
- W2022303561 hasConceptScore W2022303561C170493617 @default.
- W2022303561 hasConceptScore W2022303561C185592680 @default.
- W2022303561 hasConceptScore W2022303561C2776175493 @default.
- W2022303561 hasConceptScore W2022303561C2776885963 @default.
- W2022303561 hasConceptScore W2022303561C2777010014 @default.
- W2022303561 hasConceptScore W2022303561C2777344606 @default.