Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022303758> ?p ?o ?g. }
- W2022303758 endingPage "399" @default.
- W2022303758 startingPage "391" @default.
- W2022303758 abstract "Protein instability during microencapsulation has been one of the major drawbacks of protein delivery systems. In this study, the effects of various excipients (poly vinyl alcohol, glucose, starch, heparin) on the stability of encapsulated human immunoglobulin G (IgG) in poly(ε-caprolactone) (PCL) microspheres and on microsphere characteristics were investigated before and after γ-sterilization. Microspheres formulated without any excipients and with glucose had a mean particle size around 3–4 μm whereas the mean particle sizes of other microspheres were around 5–6 μm. Use of PVA significantly increased the IgG-loading and encapsulation efficiency of microspheres. After γ-irradiation, IgG stability was mostly maintained in the microspheres with excipients compared to microspheres without any excipients. According to the μBCA results, microspheres without any excipient showed a high initial burst release as well as a fast release profile among all groups. Presence of PVA decreased the loss in the activity of IgG released before (completely retained after 6 h and 15.69% loss after 7 days) and after γ-irradiation (26.04% loss and 52.39% loss after 6 h and 7 days, respectively). The stabilization effect of PVA on the retention of the activity of released IgG was found more efficient compared to other groups formulated with carbohydrates." @default.
- W2022303758 created "2016-06-24" @default.
- W2022303758 creator A5013900016 @default.
- W2022303758 creator A5024684590 @default.
- W2022303758 creator A5040493552 @default.
- W2022303758 date "2015-03-01" @default.
- W2022303758 modified "2023-10-16" @default.
- W2022303758 title "Influence of excipients on characteristics and release profiles of poly(ε-caprolactone) microspheres containing immunoglobulin G" @default.
- W2022303758 cites W1564460371 @default.
- W2022303758 cites W1569213843 @default.
- W2022303758 cites W1576437441 @default.
- W2022303758 cites W1580407891 @default.
- W2022303758 cites W1964067510 @default.
- W2022303758 cites W1967893470 @default.
- W2022303758 cites W1976512510 @default.
- W2022303758 cites W1984418916 @default.
- W2022303758 cites W1986901350 @default.
- W2022303758 cites W1998121317 @default.
- W2022303758 cites W1999501080 @default.
- W2022303758 cites W1999619609 @default.
- W2022303758 cites W2005438525 @default.
- W2022303758 cites W2006211285 @default.
- W2022303758 cites W2019764207 @default.
- W2022303758 cites W2020386751 @default.
- W2022303758 cites W2025292917 @default.
- W2022303758 cites W2039620000 @default.
- W2022303758 cites W2044551208 @default.
- W2022303758 cites W2051490011 @default.
- W2022303758 cites W2056428286 @default.
- W2022303758 cites W2059421179 @default.
- W2022303758 cites W2076120046 @default.
- W2022303758 cites W2076224340 @default.
- W2022303758 cites W2076504028 @default.
- W2022303758 cites W2081641593 @default.
- W2022303758 cites W2081777093 @default.
- W2022303758 cites W2089863147 @default.
- W2022303758 cites W2093240759 @default.
- W2022303758 cites W2103940834 @default.
- W2022303758 cites W2115439624 @default.
- W2022303758 cites W2135035353 @default.
- W2022303758 cites W2147455405 @default.
- W2022303758 cites W2148192899 @default.
- W2022303758 cites W2153097392 @default.
- W2022303758 cites W2161127726 @default.
- W2022303758 cites W2161765731 @default.
- W2022303758 cites W2163245582 @default.
- W2022303758 cites W2167686951 @default.
- W2022303758 cites W263675887 @default.
- W2022303758 cites W2915940455 @default.
- W2022303758 doi "https://doi.org/10.1016/j.msec.2014.12.044" @default.
- W2022303758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25579939" @default.
- W2022303758 hasPublicationYear "2015" @default.
- W2022303758 type Work @default.
- W2022303758 sameAs 2022303758 @default.
- W2022303758 citedByCount "8" @default.
- W2022303758 countsByYear W20223037582015 @default.
- W2022303758 countsByYear W20223037582016 @default.
- W2022303758 countsByYear W20223037582017 @default.
- W2022303758 countsByYear W20223037582020 @default.
- W2022303758 countsByYear W20223037582022 @default.
- W2022303758 countsByYear W20223037582023 @default.
- W2022303758 crossrefType "journal-article" @default.
- W2022303758 hasAuthorship W2022303758A5013900016 @default.
- W2022303758 hasAuthorship W2022303758A5024684590 @default.
- W2022303758 hasAuthorship W2022303758A5040493552 @default.
- W2022303758 hasConcept C127413603 @default.
- W2022303758 hasConcept C147789679 @default.
- W2022303758 hasConcept C15920480 @default.
- W2022303758 hasConcept C159654299 @default.
- W2022303758 hasConcept C178790620 @default.
- W2022303758 hasConcept C185592680 @default.
- W2022303758 hasConcept C187530423 @default.
- W2022303758 hasConcept C188027245 @default.
- W2022303758 hasConcept C189942447 @default.
- W2022303758 hasConcept C203014093 @default.
- W2022303758 hasConcept C2777239854 @default.
- W2022303758 hasConcept C2780666587 @default.
- W2022303758 hasConcept C2780898057 @default.
- W2022303758 hasConcept C2781111393 @default.
- W2022303758 hasConcept C42360764 @default.
- W2022303758 hasConcept C43617362 @default.
- W2022303758 hasConcept C521977710 @default.
- W2022303758 hasConcept C86803240 @default.
- W2022303758 hasConceptScore W2022303758C127413603 @default.
- W2022303758 hasConceptScore W2022303758C147789679 @default.
- W2022303758 hasConceptScore W2022303758C15920480 @default.
- W2022303758 hasConceptScore W2022303758C159654299 @default.
- W2022303758 hasConceptScore W2022303758C178790620 @default.
- W2022303758 hasConceptScore W2022303758C185592680 @default.
- W2022303758 hasConceptScore W2022303758C187530423 @default.
- W2022303758 hasConceptScore W2022303758C188027245 @default.
- W2022303758 hasConceptScore W2022303758C189942447 @default.
- W2022303758 hasConceptScore W2022303758C203014093 @default.
- W2022303758 hasConceptScore W2022303758C2777239854 @default.
- W2022303758 hasConceptScore W2022303758C2780666587 @default.
- W2022303758 hasConceptScore W2022303758C2780898057 @default.
- W2022303758 hasConceptScore W2022303758C2781111393 @default.
- W2022303758 hasConceptScore W2022303758C42360764 @default.