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• W2022304291 startingPage "1801" @default.
• W2022304291 abstract "The eight-stranded antiparallel β-barrel domain of the OmpA protein from Escherichia coli serves as a paradigm for the study of membrane assembly of integral β-structured membrane proteins. Previous studies have shown that neither the periplasmic turns nor the surface-exposed loops contain topogenic information. Consequently, the question of whether any structural constraint is imposed onto individual transmembrane β-strands is now addressed. To this end, amino acid sequences of β-strands 4, 6 and 8 were randomized. In vivo membrane assembly of mutant proteins was assayed and 288 variants were sequenced. Three parameters were found to be important for efficient membrane assembly. (i) At least four of five randomized residues with side-chains pointing towards the lipid bilayer must be hydrophobic and none of the three central residues must be charged. (ii) Side-chains pointing into the β-barrel interior must not be enlarged too much, possibly because of packing constraints. (iii) Proline residues are, in general, hardly tolerated in the transmembrane β-strands." @default.
• W2022304291 created "2016-06-24" @default.
• W2022304291 creator A5080532236 @default.
• W2022304291 date "1999-01-01" @default.
• W2022304291 modified "2023-09-23" @default.
• W2022304291 title "Membrane assembly of the Escherichia coli outer membrane protein OmpA: exploring sequence constraints on transmembrane β-strands 1 1Edited by W. Baumeister" @default.
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• W2022304291 doi "https://doi.org/10.1006/jmbi.1998.2405" @default.
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