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• W2022304791 startingPage "e115580" @default.
• W2022304791 abstract "Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the central quadruplex within this structure, and lead to an alteration of its hydrodynamic properties and stability." @default.
• W2022304791 created "2016-06-24" @default.
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• W2022304791 date "2014-12-19" @default.
• W2022304791 modified "2023-09-27" @default.
• W2022304791 title "An Improved Model for the hTERT Promoter Quadruplex" @default.
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• W2022304791 doi "https://doi.org/10.1371/journal.pone.0115580" @default.
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