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- W2022305035 startingPage "e1411" @default.
- W2022305035 abstract "The use of antibiotics targeting the obligate bacterial endosymbiont Wolbachia of filarial parasites has been validated as an approach for controlling filarial infection in animals and humans. Availability of genomic sequences for the Wolbachia (wBm) present in the human filarial parasite Brugia malayi has enabled genome-wide searching for new potential drug targets. In the present study, we investigated the cell division machinery of wBm and determined that it possesses the essential cell division gene ftsZ which was expressed in all developmental stages of B. malayi examined. FtsZ is a GTPase thereby making the protein an attractive Wolbachia drug target. We described the molecular characterization and catalytic properties of Wolbachia FtsZ. We also demonstrated that the GTPase activity was inhibited by the natural product, berberine, and small molecule inhibitors identified from a high-throughput screen. Furthermore, berberine was also effective in reducing motility and reproduction in B. malayi parasites in vitro. Our results should facilitate the discovery of selective inhibitors of FtsZ as a novel anti-symbiotic approach for controlling filarial infection. NOTE: The nucleotide sequences reported in this paper are available in GenBank™ Data Bank under the accession number wAlB-FtsZ (JN616286)." @default.
- W2022305035 created "2016-06-24" @default.
- W2022305035 creator A5011241629 @default.
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- W2022305035 date "2011-11-29" @default.
- W2022305035 modified "2023-10-18" @default.
- W2022305035 title "Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy" @default.
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- W2022305035 doi "https://doi.org/10.1371/journal.pntd.0001411" @default.
- W2022305035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3226453" @default.
- W2022305035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22140592" @default.
- W2022305035 hasPublicationYear "2011" @default.
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