Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022306793> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2022306793 endingPage "414" @default.
- W2022306793 startingPage "397" @default.
- W2022306793 abstract "The human follicle-stimulating hormone (hFSH) belongs to a family of glycoprotein hormones which contains two non-identical subunits. This paper describes the design and synthesis of a series of synthetic hFSH constructs as putative ligands for the receptor. The design of these constructs is based on the crystal structure of hCG and molecular modelling using the program package Insight II/Discover. The designed constructs contain peptides ranging from 7 to 48 amino acid residues, disulphide bridges and glycan residues. All the synthetic peptides were synthesized by the stepwise solid-phase method using Fmoc chemistry. Two of the synthetic peptides contain the glycosylated amino acid. Asn(GlcNAc-GlcNAc) and both were prepared using fully protected glycosylated building blocks in the solid-phase peptide synthesis. The disulphide bridges were formed from acetamidomethyl-protected glycopeptides and peptides by a direct deprotection/oxidation method using thallium(III) trifluoroacetate. Mass spectroscopy and amino acid analysis were used for characterization of the synthetic hFSH glycopeptides and peptides. The synthetic hFSH constructs were tested for binding activity on FSH receptor assays but none showed improved binding properties compared with the naturally occurring hormone. It was finally demonstrated that non-related peptides showed non-specific binding at the same level as reported for specific peptides." @default.
- W2022306793 created "2016-06-24" @default.
- W2022306793 creator A5008925360 @default.
- W2022306793 creator A5020579457 @default.
- W2022306793 creator A5031761308 @default.
- W2022306793 creator A5033247196 @default.
- W2022306793 creator A5072979459 @default.
- W2022306793 creator A5075530589 @default.
- W2022306793 date "1997-11-01" @default.
- W2022306793 modified "2023-09-24" @default.
- W2022306793 title "Synthetic hFSH peptide constructs in the evaluation of previous studies on the hFSH receptor interaction" @default.
- W2022306793 cites W1093746230 @default.
- W2022306793 cites W1610481818 @default.
- W2022306793 cites W1846012941 @default.
- W2022306793 cites W1966113325 @default.
- W2022306793 cites W1966349832 @default.
- W2022306793 cites W1967235742 @default.
- W2022306793 cites W1967427178 @default.
- W2022306793 cites W1983731033 @default.
- W2022306793 cites W2003589733 @default.
- W2022306793 cites W2004610998 @default.
- W2022306793 cites W2004681561 @default.
- W2022306793 cites W2008494805 @default.
- W2022306793 cites W2031192188 @default.
- W2022306793 cites W2040764971 @default.
- W2022306793 cites W2050971119 @default.
- W2022306793 cites W2063812873 @default.
- W2022306793 cites W2071168359 @default.
- W2022306793 cites W2085384400 @default.
- W2022306793 cites W2094243088 @default.
- W2022306793 cites W2107199486 @default.
- W2022306793 cites W2113235351 @default.
- W2022306793 cites W2127353687 @default.
- W2022306793 cites W2320556745 @default.
- W2022306793 doi "https://doi.org/10.1002/(sici)1099-1387(199711)3:6<397::aid-psc113>3.0.co;2-k" @default.
- W2022306793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9467969" @default.
- W2022306793 hasPublicationYear "1997" @default.
- W2022306793 type Work @default.
- W2022306793 sameAs 2022306793 @default.
- W2022306793 citedByCount "3" @default.
- W2022306793 crossrefType "journal-article" @default.
- W2022306793 hasAuthorship W2022306793A5008925360 @default.
- W2022306793 hasAuthorship W2022306793A5020579457 @default.
- W2022306793 hasAuthorship W2022306793A5031761308 @default.
- W2022306793 hasAuthorship W2022306793A5033247196 @default.
- W2022306793 hasAuthorship W2022306793A5072979459 @default.
- W2022306793 hasAuthorship W2022306793A5075530589 @default.
- W2022306793 hasConcept C104317684 @default.
- W2022306793 hasConcept C108625454 @default.
- W2022306793 hasConcept C137610392 @default.
- W2022306793 hasConcept C167625842 @default.
- W2022306793 hasConcept C170493617 @default.
- W2022306793 hasConcept C185592680 @default.
- W2022306793 hasConcept C206212055 @default.
- W2022306793 hasConcept C21951064 @default.
- W2022306793 hasConcept C2776469878 @default.
- W2022306793 hasConcept C2779281246 @default.
- W2022306793 hasConcept C2779809887 @default.
- W2022306793 hasConcept C501593827 @default.
- W2022306793 hasConcept C515207424 @default.
- W2022306793 hasConcept C55493867 @default.
- W2022306793 hasConcept C71240020 @default.
- W2022306793 hasConceptScore W2022306793C104317684 @default.
- W2022306793 hasConceptScore W2022306793C108625454 @default.
- W2022306793 hasConceptScore W2022306793C137610392 @default.
- W2022306793 hasConceptScore W2022306793C167625842 @default.
- W2022306793 hasConceptScore W2022306793C170493617 @default.
- W2022306793 hasConceptScore W2022306793C185592680 @default.
- W2022306793 hasConceptScore W2022306793C206212055 @default.
- W2022306793 hasConceptScore W2022306793C21951064 @default.
- W2022306793 hasConceptScore W2022306793C2776469878 @default.
- W2022306793 hasConceptScore W2022306793C2779281246 @default.
- W2022306793 hasConceptScore W2022306793C2779809887 @default.
- W2022306793 hasConceptScore W2022306793C501593827 @default.
- W2022306793 hasConceptScore W2022306793C515207424 @default.
- W2022306793 hasConceptScore W2022306793C55493867 @default.
- W2022306793 hasConceptScore W2022306793C71240020 @default.
- W2022306793 hasIssue "6" @default.
- W2022306793 hasLocation W20223067931 @default.
- W2022306793 hasLocation W20223067932 @default.
- W2022306793 hasOpenAccess W2022306793 @default.
- W2022306793 hasPrimaryLocation W20223067931 @default.
- W2022306793 hasRelatedWork W179506288 @default.
- W2022306793 hasRelatedWork W1979844878 @default.
- W2022306793 hasRelatedWork W2019409337 @default.
- W2022306793 hasRelatedWork W2026459752 @default.
- W2022306793 hasRelatedWork W2038603120 @default.
- W2022306793 hasRelatedWork W2041084343 @default.
- W2022306793 hasRelatedWork W2057887938 @default.
- W2022306793 hasRelatedWork W2080404164 @default.
- W2022306793 hasRelatedWork W2605585491 @default.
- W2022306793 hasRelatedWork W4294292770 @default.
- W2022306793 hasVolume "3" @default.
- W2022306793 isParatext "false" @default.
- W2022306793 isRetracted "false" @default.
- W2022306793 magId "2022306793" @default.
- W2022306793 workType "article" @default.