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• W2022307179 startingPage "133" @default.
• W2022307179 abstract "The purpose of this study was to determine in a preclinical purging model, how effective crystal violet-mediated photodynamic therapy (CV-PDT) is against solid tumor and drug-resistant mutant tumor cells, and if certain limitations of CV-PDT can be overcome by using crystal violet (CV) in combination with the membrane-active photosensitizer, Merocyanine 540 (MC540). When used under conditions that preserved an adequate fraction of normal human granulocyte/macrophage progenitors (CFU-GM), CV-PDT failed to achieve meaningful reductions of DU145 prostate, H69 small cell lung cancer, and MDA-MB-435S breast cancer cells. Melphalan-resistant L1210/L-PAM1, adriamycin-resistant P388/ADR, and adriamycin-resistant HL-60/ADR leukemia cells were markedly less sensitive to CV-PDT than their wild-type counterparts, whereas cisplatin-resistant H69/CDDP cells were more sensitive than wild-type H69 cells. Sequential exposure to MC540- and CV-PDT under conditions that preserved an adequate fraction (73% and 29%, respectively) of normal CD34-positive hematopoietic stem cells and granulocyte/macrophage progenitors was highly effective against H69 (99.997% reduction) and H69/CDDP (99.999% reduction) cells, but ineffective against HL-60/ADR, MDA-MB-435S, and DU145 cells. CV thus shows only limited promise as a single-modality purging agent. However, in certain situations, clinically meaningful tumor cell depletions can be obtained by using CV in combination with a second photosensitizer such as MC540." @default.
• W2022307179 created "2016-06-24" @default.
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• W2022307179 date "2003-07-01" @default.
• W2022307179 modified "2023-10-15" @default.
• W2022307179 title "Crystal violet combined with Merocyanine 540 for the ex vivo purging of hematopoietic stem cell grafts" @default.
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• W2022307179 doi "https://doi.org/10.1016/s1011-1344(03)00073-3" @default.
• W2022307179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12962637" @default.
• W2022307179 hasPublicationYear "2003" @default.
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