Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022307600> ?p ?o ?g. }
- W2022307600 endingPage "3371" @default.
- W2022307600 startingPage "3364" @default.
- W2022307600 abstract "Abstract High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous hemoglobin C (Hb-C), and glucose-6-phosphate dehydrogenase (G6PD) deficiency in regions with high incidence of Plasmodium falciparum malaria and case-control studies support the protective role of those conditions. Protection has been attributed to defective parasite growth or to enhanced removal of the parasitized RBCs. We suggested enhanced phagocytosis of rings, the early intraerythrocytic form of the parasite, as an alternative explanation for protection in G6PD deficiency. We show here that P falciparum developed similarly in normal RBCs and in sickle trait, beta- and alpha-thalassemia trait, and HbH RBCs. We also show that membrane-bound hemichromes, autologous immunoglobulin G (IgG) and complement C3c fragments, aggregated band 3, and phagocytosis by human monocytes were remarkably higher in rings developing in all mutant RBCs considered except alpha-thalassemia trait. Phagocytosis of ring-parasitized mutant RBCs was predominantly complement mediated and very similar to phagocytosis of senescent or damaged normal RBCs. Trophozoite-parasitized normal and mutant RBCs were phagocytosed similarly in all conditions examined. Enhanced phagocytosis of ring-parasitized mutant RBCs may represent the common mechanism for malaria protection in nonimmune individuals affected by widespread RBC mutations, while individuals with alpha-thalassemia trait are likely protected by a different mechanism. (Blood. 2004;104:3364-3371)" @default.
- W2022307600 created "2016-06-24" @default.
- W2022307600 creator A5004458098 @default.
- W2022307600 creator A5005710400 @default.
- W2022307600 creator A5051452439 @default.
- W2022307600 creator A5089212521 @default.
- W2022307600 date "2004-11-15" @default.
- W2022307600 modified "2023-10-06" @default.
- W2022307600 title "Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait" @default.
- W2022307600 cites W1230104293 @default.
- W2022307600 cites W1486639332 @default.
- W2022307600 cites W1490691079 @default.
- W2022307600 cites W1496858589 @default.
- W2022307600 cites W1508266951 @default.
- W2022307600 cites W1512818335 @default.
- W2022307600 cites W1561897684 @default.
- W2022307600 cites W1571407389 @default.
- W2022307600 cites W157495653 @default.
- W2022307600 cites W1637777503 @default.
- W2022307600 cites W1805406405 @default.
- W2022307600 cites W1839327031 @default.
- W2022307600 cites W1898868640 @default.
- W2022307600 cites W196272636 @default.
- W2022307600 cites W1966159032 @default.
- W2022307600 cites W1969323970 @default.
- W2022307600 cites W1972675143 @default.
- W2022307600 cites W1978330203 @default.
- W2022307600 cites W1981018378 @default.
- W2022307600 cites W1990356699 @default.
- W2022307600 cites W2001558980 @default.
- W2022307600 cites W2002133417 @default.
- W2022307600 cites W2003951619 @default.
- W2022307600 cites W2018346661 @default.
- W2022307600 cites W2019771198 @default.
- W2022307600 cites W2020251171 @default.
- W2022307600 cites W2032272243 @default.
- W2022307600 cites W2037217034 @default.
- W2022307600 cites W2037299483 @default.
- W2022307600 cites W2043490826 @default.
- W2022307600 cites W2043503050 @default.
- W2022307600 cites W2044596656 @default.
- W2022307600 cites W2045833923 @default.
- W2022307600 cites W2052337346 @default.
- W2022307600 cites W2052563280 @default.
- W2022307600 cites W2059571377 @default.
- W2022307600 cites W2063485848 @default.
- W2022307600 cites W2070005745 @default.
- W2022307600 cites W2089981850 @default.
- W2022307600 cites W2093866426 @default.
- W2022307600 cites W2107533622 @default.
- W2022307600 cites W2107934195 @default.
- W2022307600 cites W2108667952 @default.
- W2022307600 cites W2162538153 @default.
- W2022307600 cites W2163331958 @default.
- W2022307600 cites W2264469137 @default.
- W2022307600 cites W2403555441 @default.
- W2022307600 cites W2422076661 @default.
- W2022307600 cites W2913737956 @default.
- W2022307600 cites W4230411688 @default.
- W2022307600 cites W4256209386 @default.
- W2022307600 cites W65176043 @default.
- W2022307600 doi "https://doi.org/10.1182/blood-2003-11-3820" @default.
- W2022307600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15280204" @default.
- W2022307600 hasPublicationYear "2004" @default.
- W2022307600 type Work @default.
- W2022307600 sameAs 2022307600 @default.
- W2022307600 citedByCount "312" @default.
- W2022307600 countsByYear W20223076002012 @default.
- W2022307600 countsByYear W20223076002013 @default.
- W2022307600 countsByYear W20223076002014 @default.
- W2022307600 countsByYear W20223076002015 @default.
- W2022307600 countsByYear W20223076002016 @default.
- W2022307600 countsByYear W20223076002017 @default.
- W2022307600 countsByYear W20223076002018 @default.
- W2022307600 countsByYear W20223076002019 @default.
- W2022307600 countsByYear W20223076002020 @default.
- W2022307600 countsByYear W20223076002021 @default.
- W2022307600 countsByYear W20223076002022 @default.
- W2022307600 countsByYear W20223076002023 @default.
- W2022307600 crossrefType "journal-article" @default.
- W2022307600 hasAuthorship W2022307600A5004458098 @default.
- W2022307600 hasAuthorship W2022307600A5005710400 @default.
- W2022307600 hasAuthorship W2022307600A5051452439 @default.
- W2022307600 hasAuthorship W2022307600A5089212521 @default.
- W2022307600 hasBestOaLocation W20223076001 @default.
- W2022307600 hasConcept C104317684 @default.
- W2022307600 hasConcept C111684460 @default.
- W2022307600 hasConcept C125996951 @default.
- W2022307600 hasConcept C142724271 @default.
- W2022307600 hasConcept C143065580 @default.
- W2022307600 hasConcept C159654299 @default.
- W2022307600 hasConcept C160448771 @default.
- W2022307600 hasConcept C203014093 @default.
- W2022307600 hasConcept C2776557347 @default.
- W2022307600 hasConcept C2777566322 @default.
- W2022307600 hasConcept C2777799968 @default.
- W2022307600 hasConcept C2778048844 @default.
- W2022307600 hasConcept C2778371730 @default.