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- W2022307987 abstract "The purpose of the present study was to investigate transcripts of perforin, granzyme B, and Fas ligand (FasL) in heart transplants undergoing rejection.Quantitative reverse transcriptase-polymerase chain reaction was applied for mRNA detection in 29 endomyocardial biopsy specimens from 11 cardiac allograft recipients.The mRNA levels of granzyme B, perforin, and FasL were higher (P<0.05) in biopsy specimens with rejection than in biopsy specimens without rejection (granzyme B, 0.53 vs. 0.09; perforin, 0.34 vs. 0; FasL, 0.57 vs. 0.36). In prerejection biopsy specimens, granzyme B and FasL levels were significantly higher than in biopsy specimens without rejection. Any two of the three transcripts were increased in 100% of prerejection, in 92% of rejection, and in 36% of no rejection biopsy specimens (P<0.04).The assessment of intragraft levels of cytotoxic T lymphocyte effector molecule mRNA represents a valuable tool in the monitoring of cardiac allograft rejection, especially considering the predictive value for warning of impending acute rejection." @default.
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- W2022307987 date "2001-11-01" @default.
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- W2022307987 title "INTRAGRAFT ACTIVATION OF GENES ENCODING CYTOTOXIC T LYMPHOCYTE EFFECTOR MOLECULES PRECEDES THE HISTOLOGICAL EVIDENCE OF REJECTION IN HUMAN CARDIAC TRANSPLANTATION1" @default.
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- W2022307987 doi "https://doi.org/10.1097/00007890-200111270-00025" @default.
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