FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022308684> ?p ?o ?g. }

• W2022308684 endingPage "e56687" @default.
• W2022308684 startingPage "e56687" @default.
• W2022308684 abstract "Staphylococcus aureus is an important human pathogen in both hospital and the community that has demonstrated resistance to all currently available antibiotics over the last two decades. Multidrug-resistant isolates of methicillin-resistant S. aureus (MRSA) exhibiting decreased susceptibilities to glycopeptides has also emerged, representing a crucial challenge for antimicrobial therapy and infection control. The availability of complete whole-genome nucleotide sequence data of various strains of S. aureus presents an opportunity to explore novel compounds and their targets to address the challenges presented by antimicrobial drug resistance in this organism. Study compounds α-amyrin [3β-hydroxy-urs-12-en-3-ol (AM)], betulinic acid [3β-hydroxy-20(29)-lupaene-28-oic acid (BA)] and betulinaldehyde [3β-hydroxy-20(29)-lupen-28-al (BE)] belong to pentacyclic triterpenoids and were reported to exhibit antimicrobial activities against bacteria and fungi, including S. aureus. The MIC values of these compounds against a reference strain of methicillin-resistant S. aureus (MRSA) (ATCC 43300) ranged from 64 µg/ml to 512 µg/ml. However, the response mechanisms of S. aureus to these compounds are still poorly understood. The transcription profile of reference strain of MRSA treated with sub-inhibitory concentrations of the three compounds was determined using Affymetrix GeneChips. The findings showed that these compounds regulate multiple desirable targets in cell division, two-component system, ABC transporters, fatty acid biosynthesis, peptidoglycan biosynthesis, aminoacyl-tRNA synthetase, ribosome and β-lactam resistance pathways which could be further explored in the development of therapeutic agents for the treatment of S. aureus infections." @default.
• W2022308684 created "2016-06-24" @default.
• W2022308684 creator A5010607786 @default.
• W2022308684 creator A5017837253 @default.
• W2022308684 creator A5088259684 @default.
• W2022308684 date "2013-02-20" @default.
• W2022308684 modified "2023-09-23" @default.
• W2022308684 title "Transcriptional Profiles of the Response of Methicillin-Resistant Staphylococcus aureus to Pentacyclic Triterpenoids" @default.
• W2022308684 cites W1877167201 @default.
• W2022308684 cites W1964246898 @default.
• W2022308684 cites W1965518068 @default.
• W2022308684 cites W1970783326 @default.
• W2022308684 cites W1979553232 @default.
• W2022308684 cites W1980810776 @default.
• W2022308684 cites W1989889086 @default.
• W2022308684 cites W1993562651 @default.
• W2022308684 cites W1998751975 @default.
• W2022308684 cites W2003757150 @default.
• W2022308684 cites W2005056854 @default.
• W2022308684 cites W2006095863 @default.
• W2022308684 cites W2007331931 @default.
• W2022308684 cites W2020610502 @default.
• W2022308684 cites W2022147692 @default.
• W2022308684 cites W2035800315 @default.
• W2022308684 cites W2043524498 @default.
• W2022308684 cites W2046653681 @default.
• W2022308684 cites W2051818263 @default.
• W2022308684 cites W2063040166 @default.
• W2022308684 cites W2090192352 @default.
• W2022308684 cites W2092196558 @default.
• W2022308684 cites W2097536855 @default.
• W2022308684 cites W2098627421 @default.
• W2022308684 cites W2100932565 @default.
• W2022308684 cites W2111993374 @default.
• W2022308684 cites W2113481566 @default.
• W2022308684 cites W2115317294 @default.
• W2022308684 cites W2119084002 @default.
• W2022308684 cites W2122020611 @default.
• W2022308684 cites W2124135279 @default.
• W2022308684 cites W2130025410 @default.
• W2022308684 cites W2135986898 @default.
• W2022308684 cites W2137473832 @default.
• W2022308684 cites W2138241173 @default.
• W2022308684 cites W2148663866 @default.
• W2022308684 cites W2156588584 @default.
• W2022308684 cites W2160108381 @default.
• W2022308684 cites W2160958850 @default.
• W2022308684 cites W2167275970 @default.
• W2022308684 cites W2170347095 @default.
• W2022308684 doi "https://doi.org/10.1371/journal.pone.0056687" @default.
• W2022308684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3577688" @default.
• W2022308684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23437212" @default.
• W2022308684 hasPublicationYear "2013" @default.
• W2022308684 type Work @default.
• W2022308684 sameAs 2022308684 @default.
• W2022308684 citedByCount "21" @default.
• W2022308684 countsByYear W20223086842014 @default.
• W2022308684 countsByYear W20223086842015 @default.
• W2022308684 countsByYear W20223086842016 @default.
• W2022308684 countsByYear W20223086842017 @default.
• W2022308684 countsByYear W20223086842018 @default.
• W2022308684 countsByYear W20223086842020 @default.
• W2022308684 countsByYear W20223086842021 @default.
• W2022308684 countsByYear W20223086842022 @default.
• W2022308684 countsByYear W20223086842023 @default.
• W2022308684 crossrefType "journal-article" @default.
• W2022308684 hasAuthorship W2022308684A5010607786 @default.
• W2022308684 hasAuthorship W2022308684A5017837253 @default.
• W2022308684 hasAuthorship W2022308684A5088259684 @default.
• W2022308684 hasBestOaLocation W20223086841 @default.
• W2022308684 hasConcept C133936738 @default.
• W2022308684 hasConcept C2776634448 @default.
• W2022308684 hasConcept C2777052132 @default.
• W2022308684 hasConcept C2777334864 @default.
• W2022308684 hasConcept C2777829905 @default.
• W2022308684 hasConcept C2779489039 @default.
• W2022308684 hasConcept C4937899 @default.
• W2022308684 hasConcept C501593827 @default.
• W2022308684 hasConcept C523546767 @default.
• W2022308684 hasConcept C54355233 @default.
• W2022308684 hasConcept C86803240 @default.
• W2022308684 hasConcept C89423630 @default.
• W2022308684 hasConcept C94665300 @default.
• W2022308684 hasConceptScore W2022308684C133936738 @default.
• W2022308684 hasConceptScore W2022308684C2776634448 @default.
• W2022308684 hasConceptScore W2022308684C2777052132 @default.
• W2022308684 hasConceptScore W2022308684C2777334864 @default.
• W2022308684 hasConceptScore W2022308684C2777829905 @default.
• W2022308684 hasConceptScore W2022308684C2779489039 @default.
• W2022308684 hasConceptScore W2022308684C4937899 @default.
• W2022308684 hasConceptScore W2022308684C501593827 @default.
• W2022308684 hasConceptScore W2022308684C523546767 @default.
• W2022308684 hasConceptScore W2022308684C54355233 @default.
• W2022308684 hasConceptScore W2022308684C86803240 @default.
• W2022308684 hasConceptScore W2022308684C89423630 @default.
• W2022308684 hasConceptScore W2022308684C94665300 @default.
• W2022308684 hasIssue "2" @default.
• W2022308684 hasLocation W20223086841 @default.

• next