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- W2022308822 abstract "Abstract The oral toxicity of 5-benzyl-3-furylmethyl-(1R, cis )-chrysanthemate (cismethrin) to female rats decreased as their environmental temperature was raised. Acute oral LD 50 values increased from 157 mg/kg at 4°C to 197 mg/kg at 20°C and to > 1000 mg/kg at 30°C. Cismethrin was much more toxic given intravenously when the LD 50 was 4.5 mg/kg. This value did not change at different environmental temperatures. Irrespective of the environmental temperature, or route of adminstration, following the respective LD 50 's cismethrin caused tremors in rats when brain levels of 0.5–1.0 μg/g were reached and, at death, brain concentrations were 3.9–5.1 μg/g. These results suggested that the accumulation of cismethrin by the brain could be used as a model for the nervous system as a whole. The isomeric 5-benzyl-3-furylmethyl-(1R, trans )-chrysanthemate (bioresmethrin) was about 50 times less toxic to rats than cismethrin. After an intravenous LD 50 , tremors started when brain concentrations were 4–5 μg/g. At death, brain levels were 25–35 μg/g. Plasma esterases were about equally active in hydrolysing cismethrin and bioresmethrin, whereas liver microsomal esterases hydrolyzed bioresmethrin over 10 times more rapidly than cismethrin. It is suggested that the lower toxicity of bioresmethrin is not only due to its faster metabolism but to an intrinsically lower toxicity at the critical site of action in the nervous system." @default.
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- W2022308822 date "1976-10-01" @default.
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- W2022308822 title "The relationship between brain levels of cismethrin and bioresmethrin in female rats and neurotoxic effects" @default.
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- W2022308822 doi "https://doi.org/10.1016/0048-3575(76)90060-2" @default.
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