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• W2022308823 abstract "High breast density on mammography is associated with a four to six-fold increased risk of breast cancer [ 1 Byrne C. Schairer C. Wolfe J. et al. Mammographic features and breast cancer risk: effects with time, age, and menopause statusm. J. Natl. Cancer Inst. 1995; 87: 1622-1629 Crossref PubMed Scopus (740) Google Scholar , 2 Byng J.W. Yaffe M.J. Jong R.A. et al. Analysis of mammographic density and breast cancer risk from digitized mammograms. Radiographics. 1998; 18: 1587-1598 Crossref PubMed Scopus (206) Google Scholar ]. A review of eight cohort studies concluded that women with the highest breast density using Wolfe's method of classification compared with the lowest density have a relative risk of 5.2 (CI=3.6–7.5) for breast cancer [ [3] Warner E. Lockwood G. Tritchler D. Boyd N.F. The risk of breast cancer associated with mammographic parenchymal patterns: a meta-analysis of the published literature to examine the effect of method of classification. Cancer Detect. Prev. 1992; 16: 67-72 PubMed Google Scholar ]. Increased density is also a problem because it impairs the detection of breast masses (microcalcifications are less obscured by surrounding dense tissue than masses) [ [4] Freedman M. San Martin J. O'Gorman J. et al. Digitized mammography: a clinical trial of postmenopausal women randomly assigned to receive raloxifene, estrogen, or placebo. J. Natl. Cancer Inst. 2001; 93: 51-56 Crossref PubMed Scopus (131) Google Scholar ]. A failure to detect masses because of high density would cause an increase in interval cancers (cancers that present between mammographic screenings). Difficulties in reading high density mammograms also produce false positive recalls (patients who are recalled for assessment and found not to have cancer). Being recalled for reassessment after an initial mammogram is a cause of significant psychological stress [ [5] Ong G. Austoker J. Brett J. Breast screening: adverse psychological consequences 1 month after placing women on early recall because of a diagnostic uncertainty. A multicentre study. J. Med. Screen. 1997; 4: 158-168 PubMed Google Scholar ]. In addition, at least 25% of the overall cost of mammographic screening in one US program was attributed to investigations of false positive readings [ [6] Elmore J.G. Barton M.B. Moceri V.M. et al. Ten-year risk of false positive screening mammograms and clinical breast examinations. New Engl. J. Med. 1998; 338: 1089-1096 Crossref PubMed Scopus (906) Google Scholar ]." @default.
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• W2022308823 date "2002-03-01" @default.
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• W2022308823 title "The meaning of mammographic breast density in users of postmenopausal hormone therapy" @default.
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• W2022308823 doi "https://doi.org/10.1016/s0378-5122(02)00006-3" @default.
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