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• W2022308886 endingPage "37" @default.
• W2022308886 startingPage "29" @default.
• W2022308886 abstract "Summary: The present study was undertaken to explore a potential interaction of endothelin-1 (ET-1) on vasopressin (AVP)-dependent cyclic 3′,5′-adenosine monophosphate (cAMP) and atrial natriuretic peptide (ANP)-dependent cyclic 3′,5′-guanosine monophosphate (cGMP) metabolisms in primary cultured rat inner medullary collecting duct (IMCD) cells. Endothelin-1 did not affect ANP-stimulated cGMP accumulation in the presence or absence of 3-isobutyl-1-methylxanthine (IBMX). Levels of 10−10 to 10−7 mol/LET-1 showed a dose-dependent inhibition of the AVP-dependent cAMP accumulation in the presence of IBMX and 10−7 mol/LET-1 inhibited the cAMP generation by 34 ± 5.3% (n= 5, n= 20, P<0.01). Endothelin-1 did not affect the cAMP generation either by 100 ng/mL cholera toxin or by 10−4 mol/L forskolin. Endothelin-1 failed to inhibit the cAMP generation in the presence of 100 ng/mL pertussis toxin (PTX). the inhibitory effect of ET-1 was reversed by 10−8 mol/L staurosporin (SSP), a protein kinase C (PKC) inhibitor. Furthermore, this inhibitory effect of ET-1 was mimicked by 10−8 mol/L phorbol 12-myristate 13-acetate (PMA), an activator of PKC. A dose of 5 × 10−6 mol/L indomethacin did not affect this inhibitory effect of ET-1. From these results, we suggest that the effect of ET-1 on cyclic nucleotides metabolism seem to be selective. Endothelin-1 did not affect the cGMP generation by ANP, whereas it inhibited cAMP production by AVP via PTX and SSP sensitive pathway in cultured rat IMCD cells." @default.
• W2022308886 created "2016-06-24" @default.
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• W2022308886 date "1996-02-01" @default.
• W2022308886 modified "2023-09-26" @default.
• W2022308886 title "Endothelin-1 affects AVP-stimulated cAMP but not ANP-induced cGMP productions in cultured rat IMCD cells" @default.
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• W2022308886 doi "https://doi.org/10.1111/j.1440-1797.1996.tb00063.x" @default.
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